357 lines
10 KiB
YAML
357 lines
10 KiB
YAML
abstract: 'IntroductionTreat All - the treatment of all people with HIV,
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irrespective of disease stage or CD4 cell count - represents a paradigm
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shift in HIV care that has the potential to end AIDS as a public health
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threat. With accelerating implementation of Treat All in sub-Saharan
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Africa (SSA), there is a need for a focused agenda and research to
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identify and inform strategies for promoting timely uptake of HIV
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treatment, retention in care, and sustained viral suppression and
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addressing bottlenecks impeding implementation.
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MethodsThe Delphi approach was used to develop consensus around research
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priorities for Treat All implementation in SSA. Through an iterative
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process (June 2017 to March 2018), a set of research priorities was
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collectively formulated and refined by a technical working group and
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shared for review, deliberation and prioritization by more than 200
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researchers, implementation experts, policy/decision-makers, and HIV
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community representatives in East, Central, Southern and West Africa.
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Results and discussionThe process resulted in a list of nine research
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priorities for generating evidence to guide Treat All policies,
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implementation strategies and monitoring efforts. These priorities
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highlight the need for increased focus on adolescents, men, and those
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with mental health and substance use disorders - groups that remain
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underserved in SSA and for whom more effective testing, linkage and care
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strategies need to be identified. The priorities also reflect consensus
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on the need to: (1) generate accurate national and sub-national
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estimates of the size of key populations and describe those who remain
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underserved along the HIV-care continuum; (2) characterize the
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timeliness of HIV care and short- and long-term HIV care continuum
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outcomes, as well as factors influencing timely achievement of these
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outcomes; (3) estimate the incidence and prevalence of HIV-drug
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resistance and regimen switching; and (4) identify cost-effective and
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affordable service delivery models and strategies to optimize uptake and
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minimize gaps, disparities, and losses along the HIV-care continuum,
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particularly among underserved populations.
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ConclusionsReflecting consensus among a broad group of experts,
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researchers, policy- and decision-makers, PLWH, and other stakeholders,
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the resulting research priorities highlight important evidence gaps that
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are relevant for ministries of health, funders, normative bodies and
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research networks.'
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affiliation: 'Nash, D (Corresponding Author), CUNY ISPH 55 West 125th St,6th Floor,
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New York, NY 10027 USA.
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Nash, D (Corresponding Author), CUNY, Inst Implementat Sci Populat Hlth, New York,
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NY 10021 USA.
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Nash, D (Corresponding Author), CUNY, Grad Sch Publ Hlth \& Hlth Policy, Dept Epidemiol
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\& Biostat, New York, NY 10021 USA.
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Yotebieng, Marcel; Lancaster, Kathryn E.; Agler, Robert, Ohio State Univ, Columbus,
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OH 43210 USA.
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Brazier, Ellen; Addison, Diane; Wikramanayake, Radhika; Nash, Denis, CUNY, Inst
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Implementat Sci Populat Hlth, New York, NY 10021 USA.
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Brazier, Ellen; Addison, Diane; Wikramanayake, Radhika; Nash, Denis, CUNY, Grad
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Sch Publ Hlth \& Hlth Policy, Dept Epidemiol \& Biostat, New York, NY 10021 USA.
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Kimmel, April D.; Bono, Rose S., Virginia Commonwealth Univ, Dept Hlth Behav \&
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Policy, Sch Med, Richmond, VA USA.
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Cornell, Morna, Univ Cape Town, Sch Publ Hlth \& Family Med, Ctr Infect Dis Epidemiol
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\& Res, Cape Town, South Africa.
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Keiser, Olivia, Univ Geneva, Inst Global Hlth, Geneva, Switzerland.
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Parcesepe, Angela M.; Onovo, Amobi, Univ N Carolina, Chapel Hill, NC 27515 USA.
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Castelnuovo, Barbara, Makerere Univ, Infect Dis Inst, Kampala, Uganda.
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Murnane, Pamela M., Univ Calif San Francisco, Dept Med, Ctr AIDS Prevent Studies,
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San Francisco, CA USA.
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Cohen, Craig R., Univ Calif San Francisco, Dept Obstet Gynecol \& Reprod Sci, Bixby
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Ctr Global Reprod Hlth, San Francisco, CA USA.
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Vreeman, Rachel C., Indiana Univ Sch Med, Dept Pediat, Indianapolis, IN 46202 USA.
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Davies, Mary-Ann, Univ Cape Town, Fac Hlth Sci, Sch Publ Hlth \& Family Med, Cape
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Town, South Africa.
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Duda, Stephany N., Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA.
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Yiannoutsos, Constantin T., Fairbanks Sch Publ Hlth, Indianapolis, IN USA.
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Bernard, Charlotte, Univ Bordeaux, Sch Publ Hlth ISPED, INSERM, Ctr Epidemiol Biostat,U1219,
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Bordeaux, France.
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Syvertsen, Jennifer L., Univ Calif Riverside, Dept Anthropol, Riverside, CA 92521
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USA.
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Sinayobye, Jean d''Amour, Rwanda Mil Hosp, Kigali, Rwanda.
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Sohn, Annette H., AmfAR, TREAT Asia, Bangkok, Thailand.
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von Groote, Per M.; Wandeler, Gilles, Univ Bern, ISPM, Bern, Switzerland.
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Leroy, Valeriane, Univ Toulouse 3, UMR 1027, French Inst Hlth \& Med Res, INSERM,
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Toulouse, France.
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Williams, Carolyn F., NIAID, Epidemiol Branch, Div AIDS, NIH, Rockville, MD USA.
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Wools-Kaloustian, Kara, Indiana Univ Sch Med, Indianapolis, IN 46202 USA.'
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article-number: e25218
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author: Yotebieng, Marcel and Brazier, Ellen and Addison, Diane and Kimmel, April
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D. and Cornell, Morna and Keiser, Olivia and Parcesepe, Angela M. and Onovo, Amobi
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and Lancaster, Kathryn E. and Castelnuovo, Barbara and Murnane, Pamela M. and Cohen,
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Craig R. and Vreeman, Rachel C. and Davies, Mary-Ann and Duda, Stephany N. and Yiannoutsos,
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Constantin T. and Bono, Rose S. and Agler, Robert and Bernard, Charlotte and Syvertsen,
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Jennifer L. and Sinayobye, Jean d'Amour and Wikramanayake, Radhika and Sohn, Annette
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H. and von Groote, Per M. and Wandeler, Gilles and Leroy, Valeriane and Williams,
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Carolyn F. and Wools-Kaloustian, Kara and Nash, Denis and Addison, Diane and Althoff,
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Keri and Brazier, Ellen and Casteln-Uovo, Barbara and Cohen, Craig R. and Cornell,
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Morna and Davies, Mary-Ann and Dominguez, Geral-Dina and Duda, Stephany N. and Freeman,
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Aimee and Jaquet, Antoine and Keiser, Olivia and Kimmel, April D. and Lancaster,
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Kathryn E. and Leroy, Valeriane and Markus, Janne and McKaig, Rosemary and Murnane,
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Pamela M. and Nash, Denis and Nsonde, Dominique and Onovo, Amobi and Parcesepe,
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Angela M. and Sinayobye, Jean d'Amour and Sohn, Ann-Ette H. and Von Groote, Per
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M. and Vreeman, Rachel C. and Wandeler, Gilles and Wikramanayake, Radhika and Williams,
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Carolyn F. and Wools-Kaloustian, Kara and Yiannoutsos, Constantin and Yotebieng,
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Marcel and Co, IeDEA Treat Sub-Saharan Africa
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author-email: denis.nash@sph.cuny.edu
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author_list:
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- family: Yotebieng
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given: Marcel
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- family: Brazier
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given: Ellen
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- family: Addison
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given: Diane
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- family: Kimmel
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given: April D.
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- family: Cornell
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given: Morna
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- family: Keiser
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given: Olivia
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- family: Parcesepe
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given: Angela M.
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- family: Onovo
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given: Amobi
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- family: Lancaster
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given: Kathryn E.
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- family: Castelnuovo
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given: Barbara
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- family: Murnane
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given: Pamela M.
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- family: Cohen
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given: Craig R.
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- family: Vreeman
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given: Rachel C.
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- family: Davies
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given: Mary-Ann
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- family: Duda
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given: Stephany N.
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- family: Yiannoutsos
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given: Constantin T.
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- family: Bono
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given: Rose S.
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- family: Agler
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given: Robert
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- family: Bernard
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given: Charlotte
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- family: Syvertsen
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given: Jennifer L.
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- family: Sinayobye
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given: Jean d'Amour
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- family: Wikramanayake
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given: Radhika
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- family: Sohn
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given: Annette H.
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- family: von Groote
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given: Per M.
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- family: Wandeler
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given: Gilles
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- family: Leroy
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given: Valeriane
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- family: Williams
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given: Carolyn F.
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- family: Wools-Kaloustian
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given: Kara
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- family: Nash
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given: Denis
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- family: Addison
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given: Diane
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- family: Althoff
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given: Keri
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- family: Brazier
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given: Ellen
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- family: Casteln-Uovo
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given: Barbara
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- family: Cohen
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given: Craig R.
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- family: Cornell
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given: Morna
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- family: Davies
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given: Mary-Ann
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- family: Dominguez
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given: Geral-Dina
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- family: Duda
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given: Stephany N.
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- family: Freeman
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given: Aimee
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- family: Jaquet
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given: Antoine
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- family: Keiser
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given: Olivia
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- family: Kimmel
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given: April D.
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- family: Lancaster
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given: Kathryn E.
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- family: Leroy
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given: Valeriane
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- family: Markus
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given: Janne
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- family: McKaig
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given: Rosemary
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- family: Murnane
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given: Pamela M.
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- family: Nash
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given: Denis
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- family: Nsonde
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given: Dominique
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- family: Onovo
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given: Amobi
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- family: Parcesepe
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given: Angela M.
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- family: Sinayobye
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given: Jean d'Amour
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- family: Sohn
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given: Ann-Ette H.
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- family: Von Groote
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given: Per M.
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- family: Vreeman
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given: Rachel C.
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- family: Wandeler
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given: Gilles
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- family: Wikramanayake
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given: Radhika
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- family: Williams
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given: Carolyn F.
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- family: Wools-Kaloustian
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given: Kara
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- family: Yiannoutsos
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given: Constantin
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- family: Yotebieng
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given: Marcel
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- family: Co
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given: IeDEA Treat Sub-Saharan Africa
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da: '2023-09-28'
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doi: 10.1002/jia2.25218
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eissn: 1758-2652
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files: []
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journal: JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
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keywords: 'Treat All; universal HIV treatment; 90-90-90 targets; sub-Saharan
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Africa; implementation science'
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keywords-plus: 'MIDDLE-INCOME COUNTRIES; FEMALE SEX WORKERS; INJECTING DRUG-USE;
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ANTIRETROVIRAL THERAPY; MENTAL-HEALTH; SUBSTANCE-USE; VIRAL SUPPRESSION;
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COST-EFFECTIVENESS; SERVICE DELIVERY; USE DISORDERS'
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language: English
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month: JAN
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number: '1'
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number-of-cited-references: '137'
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orcid-numbers: 'Leroy, Valeriane/0000-0003-3542-8616
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Leroy, Valeriane/0000-0003-3542-8616
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Leroy, Valeriane/0000-0003-3542-8616
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Jaquet, Antoine/0000-0002-3426-9492
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Yotebieng, Marcel/0000-0003-2110-2631
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Cornell, Morna/0000-0001-7149-8799
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Bernard, Charlotte/0000-0003-2677-4023
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Althoff, Keri/0000-0002-5068-6595
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von Groote, Per/0009-0005-5179-4423
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Syvertsen, Jennifer/0000-0002-2387-7273
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Nash, Denis/0000-0002-3280-5386
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Lancaster, Kathryn/0000-0003-2389-6973
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Castelnuovo, Barbara/0000-0001-7756-5032'
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papis_id: 04ba2584d9f3d607c1620e8d6d7976be
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ref: Yotebieng2019researchpriorities
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researcherid-numbers: 'Leroy, Valeriane/AAO-5175-2020
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Leroy, Valeriane/F-8129-2013
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Leroy, Valeriane/GQB-1102-2022
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Althoff, Keri N/HGC-5595-2022
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Wandeler, Gilles/ABB-2961-2020
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Nash, Denis/AFI-7485-2022
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Syvertsen, Jennifer/AAO-9292-2020
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Jaquet, Antoine/T-2794-2019
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Yotebieng, Marcel/L-2083-2013
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'
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tags:
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- review
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times-cited: '20'
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title: 'Research priorities to inform ``Treat All″ policy implementation for people
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living with HIV in sub-Saharan Africa: a consensus statement from the International
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epidemiology Databases to Evaluate AIDS (IeDEA)'
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type: Review
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unique-id: WOS:000457705500001
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usage-count-last-180-days: '0'
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usage-count-since-2013: '7'
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volume: '22'
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web-of-science-categories: Immunology; Infectious Diseases
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year: '2019'
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