abstract: 'IntroductionTreat All - the treatment of all people with HIV,

  irrespective of disease stage or CD4 cell count - represents a paradigm

  shift in HIV care that has the potential to end AIDS as a public health

  threat. With accelerating implementation of Treat All in sub-Saharan

  Africa (SSA), there is a need for a focused agenda and research to

  identify and inform strategies for promoting timely uptake of HIV

  treatment, retention in care, and sustained viral suppression and

  addressing bottlenecks impeding implementation.

  MethodsThe Delphi approach was used to develop consensus around research

  priorities for Treat All implementation in SSA. Through an iterative

  process (June 2017 to March 2018), a set of research priorities was

  collectively formulated and refined by a technical working group and

  shared for review, deliberation and prioritization by more than 200

  researchers, implementation experts, policy/decision-makers, and HIV

  community representatives in East, Central, Southern and West Africa.

  Results and discussionThe process resulted in a list of nine research

  priorities for generating evidence to guide Treat All policies,

  implementation strategies and monitoring efforts. These priorities

  highlight the need for increased focus on adolescents, men, and those

  with mental health and substance use disorders - groups that remain

  underserved in SSA and for whom more effective testing, linkage and care

  strategies need to be identified. The priorities also reflect consensus

  on the need to: (1) generate accurate national and sub-national

  estimates of the size of key populations and describe those who remain

  underserved along the HIV-care continuum; (2) characterize the

  timeliness of HIV care and short- and long-term HIV care continuum

  outcomes, as well as factors influencing timely achievement of these

  outcomes; (3) estimate the incidence and prevalence of HIV-drug

  resistance and regimen switching; and (4) identify cost-effective and

  affordable service delivery models and strategies to optimize uptake and

  minimize gaps, disparities, and losses along the HIV-care continuum,

  particularly among underserved populations.

  ConclusionsReflecting consensus among a broad group of experts,

  researchers, policy- and decision-makers, PLWH, and other stakeholders,

  the resulting research priorities highlight important evidence gaps that

  are relevant for ministries of health, funders, normative bodies and

  research networks.'
affiliation: 'Nash, D (Corresponding Author), CUNY ISPH 55 West 125th St,6th Floor,
  New York, NY 10027 USA.

  Nash, D (Corresponding Author), CUNY, Inst Implementat Sci Populat Hlth, New York,
  NY 10021 USA.

  Nash, D (Corresponding Author), CUNY, Grad Sch Publ Hlth \& Hlth Policy, Dept Epidemiol
  \& Biostat, New York, NY 10021 USA.

  Yotebieng, Marcel; Lancaster, Kathryn E.; Agler, Robert, Ohio State Univ, Columbus,
  OH 43210 USA.

  Brazier, Ellen; Addison, Diane; Wikramanayake, Radhika; Nash, Denis, CUNY, Inst
  Implementat Sci Populat Hlth, New York, NY 10021 USA.

  Brazier, Ellen; Addison, Diane; Wikramanayake, Radhika; Nash, Denis, CUNY, Grad
  Sch Publ Hlth \& Hlth Policy, Dept Epidemiol \& Biostat, New York, NY 10021 USA.

  Kimmel, April D.; Bono, Rose S., Virginia Commonwealth Univ, Dept Hlth Behav \&
  Policy, Sch Med, Richmond, VA USA.

  Cornell, Morna, Univ Cape Town, Sch Publ Hlth \& Family Med, Ctr Infect Dis Epidemiol
  \& Res, Cape Town, South Africa.

  Keiser, Olivia, Univ Geneva, Inst Global Hlth, Geneva, Switzerland.

  Parcesepe, Angela M.; Onovo, Amobi, Univ N Carolina, Chapel Hill, NC 27515 USA.

  Castelnuovo, Barbara, Makerere Univ, Infect Dis Inst, Kampala, Uganda.

  Murnane, Pamela M., Univ Calif San Francisco, Dept Med, Ctr AIDS Prevent Studies,
  San Francisco, CA USA.

  Cohen, Craig R., Univ Calif San Francisco, Dept Obstet Gynecol \& Reprod Sci, Bixby
  Ctr Global Reprod Hlth, San Francisco, CA USA.

  Vreeman, Rachel C., Indiana Univ Sch Med, Dept Pediat, Indianapolis, IN 46202 USA.

  Davies, Mary-Ann, Univ Cape Town, Fac Hlth Sci, Sch Publ Hlth \& Family Med, Cape
  Town, South Africa.

  Duda, Stephany N., Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA.

  Yiannoutsos, Constantin T., Fairbanks Sch Publ Hlth, Indianapolis, IN USA.

  Bernard, Charlotte, Univ Bordeaux, Sch Publ Hlth ISPED, INSERM, Ctr Epidemiol Biostat,U1219,
  Bordeaux, France.

  Syvertsen, Jennifer L., Univ Calif Riverside, Dept Anthropol, Riverside, CA 92521
  USA.

  Sinayobye, Jean d''Amour, Rwanda Mil Hosp, Kigali, Rwanda.

  Sohn, Annette H., AmfAR, TREAT Asia, Bangkok, Thailand.

  von Groote, Per M.; Wandeler, Gilles, Univ Bern, ISPM, Bern, Switzerland.

  Leroy, Valeriane, Univ Toulouse 3, UMR 1027, French Inst Hlth \& Med Res, INSERM,
  Toulouse, France.

  Williams, Carolyn F., NIAID, Epidemiol Branch, Div AIDS, NIH, Rockville, MD USA.

  Wools-Kaloustian, Kara, Indiana Univ Sch Med, Indianapolis, IN 46202 USA.'
article-number: e25218
author: Yotebieng, Marcel and Brazier, Ellen and Addison, Diane and Kimmel, April
  D. and Cornell, Morna and Keiser, Olivia and Parcesepe, Angela M. and Onovo, Amobi
  and Lancaster, Kathryn E. and Castelnuovo, Barbara and Murnane, Pamela M. and Cohen,
  Craig R. and Vreeman, Rachel C. and Davies, Mary-Ann and Duda, Stephany N. and Yiannoutsos,
  Constantin T. and Bono, Rose S. and Agler, Robert and Bernard, Charlotte and Syvertsen,
  Jennifer L. and Sinayobye, Jean d'Amour and Wikramanayake, Radhika and Sohn, Annette
  H. and von Groote, Per M. and Wandeler, Gilles and Leroy, Valeriane and Williams,
  Carolyn F. and Wools-Kaloustian, Kara and Nash, Denis and Addison, Diane and Althoff,
  Keri and Brazier, Ellen and Casteln-Uovo, Barbara and Cohen, Craig R. and Cornell,
  Morna and Davies, Mary-Ann and Dominguez, Geral-Dina and Duda, Stephany N. and Freeman,
  Aimee and Jaquet, Antoine and Keiser, Olivia and Kimmel, April D. and Lancaster,
  Kathryn E. and Leroy, Valeriane and Markus, Janne and McKaig, Rosemary and Murnane,
  Pamela M. and Nash, Denis and Nsonde, Dominique and Onovo, Amobi and Parcesepe,
  Angela M. and Sinayobye, Jean d'Amour and Sohn, Ann-Ette H. and Von Groote, Per
  M. and Vreeman, Rachel C. and Wandeler, Gilles and Wikramanayake, Radhika and Williams,
  Carolyn F. and Wools-Kaloustian, Kara and Yiannoutsos, Constantin and Yotebieng,
  Marcel and Co, IeDEA Treat Sub-Saharan Africa
author-email: denis.nash@sph.cuny.edu
author_list:
- family: Yotebieng
  given: Marcel
- family: Brazier
  given: Ellen
- family: Addison
  given: Diane
- family: Kimmel
  given: April D.
- family: Cornell
  given: Morna
- family: Keiser
  given: Olivia
- family: Parcesepe
  given: Angela M.
- family: Onovo
  given: Amobi
- family: Lancaster
  given: Kathryn E.
- family: Castelnuovo
  given: Barbara
- family: Murnane
  given: Pamela M.
- family: Cohen
  given: Craig R.
- family: Vreeman
  given: Rachel C.
- family: Davies
  given: Mary-Ann
- family: Duda
  given: Stephany N.
- family: Yiannoutsos
  given: Constantin T.
- family: Bono
  given: Rose S.
- family: Agler
  given: Robert
- family: Bernard
  given: Charlotte
- family: Syvertsen
  given: Jennifer L.
- family: Sinayobye
  given: Jean d'Amour
- family: Wikramanayake
  given: Radhika
- family: Sohn
  given: Annette H.
- family: von Groote
  given: Per M.
- family: Wandeler
  given: Gilles
- family: Leroy
  given: Valeriane
- family: Williams
  given: Carolyn F.
- family: Wools-Kaloustian
  given: Kara
- family: Nash
  given: Denis
- family: Addison
  given: Diane
- family: Althoff
  given: Keri
- family: Brazier
  given: Ellen
- family: Casteln-Uovo
  given: Barbara
- family: Cohen
  given: Craig R.
- family: Cornell
  given: Morna
- family: Davies
  given: Mary-Ann
- family: Dominguez
  given: Geral-Dina
- family: Duda
  given: Stephany N.
- family: Freeman
  given: Aimee
- family: Jaquet
  given: Antoine
- family: Keiser
  given: Olivia
- family: Kimmel
  given: April D.
- family: Lancaster
  given: Kathryn E.
- family: Leroy
  given: Valeriane
- family: Markus
  given: Janne
- family: McKaig
  given: Rosemary
- family: Murnane
  given: Pamela M.
- family: Nash
  given: Denis
- family: Nsonde
  given: Dominique
- family: Onovo
  given: Amobi
- family: Parcesepe
  given: Angela M.
- family: Sinayobye
  given: Jean d'Amour
- family: Sohn
  given: Ann-Ette H.
- family: Von Groote
  given: Per M.
- family: Vreeman
  given: Rachel C.
- family: Wandeler
  given: Gilles
- family: Wikramanayake
  given: Radhika
- family: Williams
  given: Carolyn F.
- family: Wools-Kaloustian
  given: Kara
- family: Yiannoutsos
  given: Constantin
- family: Yotebieng
  given: Marcel
- family: Co
  given: IeDEA Treat Sub-Saharan Africa
da: '2023-09-28'
doi: 10.1002/jia2.25218
eissn: 1758-2652
files: []
journal: JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
keywords: 'Treat All; universal HIV treatment; 90-90-90 targets; sub-Saharan

  Africa; implementation science'
keywords-plus: 'MIDDLE-INCOME COUNTRIES; FEMALE SEX WORKERS; INJECTING DRUG-USE;

  ANTIRETROVIRAL THERAPY; MENTAL-HEALTH; SUBSTANCE-USE; VIRAL SUPPRESSION;

  COST-EFFECTIVENESS; SERVICE DELIVERY; USE DISORDERS'
language: English
month: JAN
number: '1'
number-of-cited-references: '137'
orcid-numbers: 'Leroy, Valeriane/0000-0003-3542-8616

  Leroy, Valeriane/0000-0003-3542-8616

  Leroy, Valeriane/0000-0003-3542-8616

  Jaquet, Antoine/0000-0002-3426-9492

  Yotebieng, Marcel/0000-0003-2110-2631

  Cornell, Morna/0000-0001-7149-8799

  Bernard, Charlotte/0000-0003-2677-4023

  Althoff, Keri/0000-0002-5068-6595

  von Groote, Per/0009-0005-5179-4423

  Syvertsen, Jennifer/0000-0002-2387-7273

  Nash, Denis/0000-0002-3280-5386

  Lancaster, Kathryn/0000-0003-2389-6973

  Castelnuovo, Barbara/0000-0001-7756-5032'
papis_id: 04ba2584d9f3d607c1620e8d6d7976be
ref: Yotebieng2019researchpriorities
researcherid-numbers: 'Leroy, Valeriane/AAO-5175-2020

  Leroy, Valeriane/F-8129-2013

  Leroy, Valeriane/GQB-1102-2022

  Althoff, Keri N/HGC-5595-2022

  Wandeler, Gilles/ABB-2961-2020

  Nash, Denis/AFI-7485-2022

  Syvertsen, Jennifer/AAO-9292-2020

  Jaquet, Antoine/T-2794-2019

  Yotebieng, Marcel/L-2083-2013

  '
tags:
- review
times-cited: '20'
title: 'Research priorities to inform ``Treat All″ policy implementation for people
  living with HIV in sub-Saharan Africa: a consensus statement from the International
  epidemiology Databases to Evaluate AIDS (IeDEA)'
type: Review
unique-id: WOS:000457705500001
usage-count-last-180-days: '0'
usage-count-since-2013: '7'
volume: '22'
web-of-science-categories: Immunology; Infectious Diseases
year: '2019'