Add wos sample results library

02-data/intermediate/wos_sample/fcb84234020a76c33174e40895cccf2f-alexander-thomas-an/info.yaml

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+abstract: 'Introduction: Over the past two decades, India has witnessed a
+
+  staggering increase in the incidence and mortality of ST-elevation
+
+  myocardial infarction (STEMI). Indians have higher rates of STEMI and
+
+  younger populations that suffer from it when compared with developed
+
+  countries. Yet, the recommended reperfusion therapy with fibrinolysis
+
+  and percutaneous coronary intervention is available only to a minority
+
+  of patients. This gap in care is a result of financial barriers, limited
+
+  healthcare infrastructure and poor knowledge and accessibility of acute
+
+  medical services for a majority of its population.
+
+  Methods and analysis: This is a prospective, multicentre,
+
+  `pretest/post-test'' quasi-experimental, community-based study. This
+
+  programme will use a `hub-and-spoke'' model of an integrated healthcare
+
+  network based on clusters of primary-care health clinics, small
+
+  hospitals and large tertiary-care facilities. It is an `all-comers''
+
+  study which will enrol consecutive patients presenting with STEMI to the
+
+  participating hospitals. The primary objectives of the study is to
+
+  improve the use of reperfusion therapy and reduce the time from first
+
+  medical contact to device or drug in STEMI patients; and to increase the
+
+  rates of early invasive risk stratification with coronary angiography
+
+  within 3-24 h of fibrinolytic therapy in eligible patients through
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+  changes in process of care. Outcomes will be measured with statistical
+
+  comparison made before and after implementing the TN-STEMI programme.
+
+  The estimated sample size is based on the Kovai Erode Pilot study, which
+
+  provided an initial work on establishing this type of programme in South
+
+  India. It will be adequately powered at 80\% with a superiority margin
+
+  of 10\% if 36 patients are enrolled per cluster or 108 patients in three
+
+  clusters. Thus, the enrolment period of 9 months will result in a sample
+
+  size of 1500 patients.
+
+  Ethics: This study will be conducted in accordance with the ethical
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+  principles that have their origin in the current Declaration of Helsinki
+
+  and `ethical guidelines for biomedical research on human participants''
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+  as laid down by the Indian Council for Medical Research. All
+
+  participating hospitals will still obtain local ethics committee
+
+  approval of the study protocol and written informed consent will be
+
+  obtained from all participants.
+
+  Dissemination and results: Our findings will be reported through
+
+  scientific publications, research conferences and public policy venues
+
+  aimed at state and local governments in India. If successful, this model
+
+  can be extended to other areas of India as well as serve as a model of
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+  STEMI systems of care for low-income and middle-income countries across
+
+  the world.'
+affiliation: 'Alexander, T (Corresponding Author), Kovai Med Ctr \& Hosp, Dept Intervent
+  Cardiol, Coimbatore, Tamil Nadu, India.
+
+  Alexander, Thomas, Kovai Med Ctr \& Hosp, Dept Intervent Cardiol, Coimbatore, Tamil
+  Nadu, India.
+
+  Victor, Suma M.; Mullasari, Ajit S., Madras Med Mission Hosp, Dept Intervent Cardiol,
+  Madras, Tamil Nadu, India.
+
+  Veerasekar, Ganesh, Kovai Med Ctr \& Hosp, Dept Epidemiol, Coimbatore, Tamil Nadu,
+  India.
+
+  Subramaniam, Kala, Lotus Clin Res Acad Pvt Ltd, Clin Res, Madras, Tamil Nadu, India.
+
+  Nallamothu, Brahmajee K., Univ Michigan, Ann Arbor, MI 48109 USA.'
+article-number: e003850
+author: Alexander, Thomas and Victor, Suma M. and Mullasari, Ajit S. and Veerasekar,
+  Ganesh and Subramaniam, Kala and Nallamothu, Brahmajee K. and Investigators, TN-STEMI
+  Programme
+author-email: tomalex41@gmail.com
+author_list:
+- family: Alexander
+  given: Thomas
+- family: Victor
+  given: Suma M.
+- family: Mullasari
+  given: Ajit S.
+- family: Veerasekar
+  given: Ganesh
+- family: Subramaniam
+  given: Kala
+- family: Nallamothu
+  given: Brahmajee K.
+- family: Investigators
+  given: TN-STEMI Programme
+da: '2023-09-28'
+doi: 10.1136/bmjopen-2013-003850
+files: []
+issn: 2044-6055
+journal: BMJ OPEN
+keywords-plus: HEART
+language: English
+number: '12'
+number-of-cited-references: '9'
+papis_id: ec821bf07ff47f3e9a08c939faa4681e
+ref: Alexander2013protocolprospective
+times-cited: '17'
+title: 'Protocol for a prospective, controlled study of assertive and timely reperfusion
+  for patients with ST-segment elevation myocardial infarction in Tamil Nadu: the
+  TN-STEMI programme'
+type: Article
+unique-id: WOS:000330541400019
+usage-count-last-180-days: '0'
+usage-count-since-2013: '4'
+volume: '3'
+web-of-science-categories: Medicine, General \& Internal
+year: '2013'