Add wos sample results library
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abstract: 'Objectives: Clinical research is a complex scientific and social
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enterprise. Our objective was to identify strategies that pediatric
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critical care trialists consider acceptable, feasible, and effective to
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improve the design and conduct randomized controlled trials in pediatric
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critical care.
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Design: Qualitative descriptive study using semistructured individual
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interviews.
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Subjects: We interviewed 26 pediatric critical care researchers from
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seven countries who have published a randomized controlled trial
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(2005-2015). We used purposive sampling to achieve diversity regarding
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researcher characteristics and randomized controlled trial
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characteristics.
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Interventions: None.
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Measurements and Main Results: Most participants (24 {[}92\%]) were from
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high-income countries, eight (31\%) had published more than one
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randomized controlled trial, 17 (65\%) had published a multicenter
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randomized controlled trial, and eight (31\%) had published a
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multinational randomized controlled trial. An important theme was
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building communitiesgroups of individuals with similar interests, shared
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experiences, and common values, bound by professional and personal
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relationships. Participants described a sense of community as a source
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of motivation and encouragement and as a means to larger, more rigorous
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trials, increasing researcher and clinician engagement and maintaining
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enthusiasm. Strategies to build communities stressed in-person
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interactions (both professional and social), capable leadership, and
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trust. Another important theme was getting started. Participants
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highlighted the importance of formal research training and high-quality
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experiential learning through collaboration on other''s projects, guided
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by effective mentorship. Also important was working within the
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systemensuring academic credit for a range of contributions, not only
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for the principal investigator role. The longitudinal notion of building
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on success was also underscored as a cross-cutting theme.
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Conclusions: Coordinated, deliberate actions to build community and
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ensure key training and practical experiences for new investigators may
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strengthen the research enterprise in pediatric critical care. These
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strategies, potentially in combination with other novel approaches, may
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vitalize clinical research in this field.'
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affiliation: 'Duffett, M (Corresponding Author), McMaster Univ, Dept Pediat, Hamilton,
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ON, Canada.
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Duffett, Mark, McMaster Univ, Dept Pediat, Hamilton, ON, Canada.
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Swinton, Marilyn; Brouwers, Melissa; Meade, Maureen; Cook, Deborah J., McMaster
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Univ, Dept Hlth Res Methods Evidence \& Impact, Hamilton, ON, Canada.
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Brouwers, Melissa, McMaster Univ, Dept Oncol, Hamilton, ON, Canada.
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Meade, Maureen; Cook, Deborah J., McMaster Univ, Dept Med, Hamilton, ON, Canada.
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McMaster Univ, Hamilton, ON, Canada.'
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author: Duffett, Mark and Swinton, Marilyn and Brouwers, Melissa and Meade, Maureen
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and Cook, Deborah J.
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author-email: duffetmc@mcmaster.ca
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author_list:
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- family: Duffett
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given: Mark
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- family: Swinton
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given: Marilyn
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- family: Brouwers
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given: Melissa
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- family: Meade
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given: Maureen
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- family: Cook
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given: Deborah J.
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da: '2023-09-28'
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doi: 10.1097/PCC.0000000000001696
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eissn: 1947-3893
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files: []
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issn: 1529-7535
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journal: PEDIATRIC CRITICAL CARE MEDICINE
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keywords: 'pediatric critical care; qualitative methods; randomized controlled
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trials; research methods'
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keywords-plus: CLINICAL-TRIALS; PUBLICATION; BARRIERS; QUALITY
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language: English
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month: NOV
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number: '11'
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number-of-cited-references: '19'
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orcid-numbers: 'Duffett, Mark/0000-0003-1705-5422
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Brouwers, Melissa/0000-0002-9699-0269'
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pages: E595-E602
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papis_id: 7b2eb50dc95fb5d3cdc078016fa47ebf
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ref: Duffett2018advancingrandomized
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researcherid-numbers: 'Duffett, Mark/B-7524-2019
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'
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times-cited: '3'
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title: 'Advancing Randomized Controlled Trials in Pediatric Critical Care: The Perspectives
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of Trialists'
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type: Article
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unique-id: WOS:000448945200005
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usage-count-last-180-days: '0'
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usage-count-since-2013: '1'
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volume: '19'
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web-of-science-categories: Critical Care Medicine; Pediatrics
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year: '2018'
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