wow-inequalities/02-data/intermediate/wos_sample/0f833212cd66aea7bfe1a2704d50fb0c-smith-rebecca-m.-an/info.yaml

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2023-09-28 14:46:10 +00:00
abstract: 'BackgroundTraumatic brain injury (TBI) is the leading cause of long-term
disability in working age adults. Recent studies show that most acute
TBI patients demonstrate vestibular features of dizziness and imbalance,
often from combined peripheral and central vestibular dysfunction.
Effective treatment for vestibular impairments post-TBI is important
given its significant adverse impact upon quality of life and employment
prospects. The most frequent peripheral vestibular disorder in acute TBI
is benign paroxysmal positional vertigo (BPPV), affecting approximately
half of acute cases. Although there is effective treatment for
idiopathic BPPV, there are no high-quality clinical data for post-TBI
BPPV regarding its prevalence, natural history, which treatment is most
effective and when is the best time to treat. In particular,
observational studies suggest post-TBI BPPV may be recurrent, indicating
that hyperacute treatment of BPPV may be futile. Given the potential
hurdles and the lack of accurate post-TBI BPPV data, the current study
was designed to provide information regarding the feasibility and
optimal design of future large-scale prospective treatment studies that
would compare different interventions and their timing for post-TBI
BPPV.MethodA multi-centre randomised mixed methods feasibility study
design was employed. We aim to recruit approximately 75 acute TBI
patients across a range of clinical severities, from three major trauma
centres in London. Patients will be randomised to one of three treatment
arms: (1) therapist-led manoeuvres, (2) patient-led exercises and (3)
advice. Participants will be re-assessed by blinded outcome assessors at
4 and 12weeks. Acceptability of the intervention will be obtained by
patient interviews at the end of their treatment and therapist
interviews at the end of the study. Primary outcomes relate to
feasibility parameters including recruitment and retention rates,
adverse events and intervention fidelity. We will also aim to provide a
more accurate estimate of the prevalence of BPPV in TBI cases on the
trauma ward.DiscussionThe multi-centre nature of our feasibility study
will inform the design of a future prospective treatment trial of BPPV
in acute TBI. Important parameters we will obtain from this study, key
for designing a future prospective treatment study, include estimating
the prevalence of BPPV in TBI patients admitted to UK major trauma
wards, and elucidating both patient and care-provider barriers in
delivering BPPV treatment.Trial registrationISRCTN, ISRCTN91943864.
Registered on 10 February 2020.'
affiliation: 'Smith, RM; Seemungal, BM (Corresponding Author), Imperial Coll London,
Dept Brain Sci, Neurootol Unit, Brain \& Vestibular Grp BAVG, London, England.
Smith, Rebecca M.; Tahtis, Vassilios; Seemungal, Barry M., Imperial Coll London,
Dept Brain Sci, Neurootol Unit, Brain \& Vestibular Grp BAVG, London, England.
Marroney, Natalie; Beattie, Jenna; Seemungal, Barry M., Imperial Coll Healthcare
NHS Trust, London, England.
Newdick, Abby, St Georges Univ Hosp NHS Fdn Trust, London, England.
Tahtis, Vassilios, Kings Coll Hosp NHS Fdn Trust, London, England.
Burgess, Caroline, Kings Coll London, Populat Hlth Sci, London, England.
Marsden, Jonathan, Univ Plymouth, Sch Hlth Profess, Plymouth, Devon, England.'
article-number: '130'
author: Smith, Rebecca M. and Marroney, Natalie and Beattie, Jenna and Newdick, Abby
and Tahtis, Vassilios and Burgess, Caroline and Marsden, Jonathan and Seemungal,
Barry M.
author-email: 'rmsmi15@ic.ac.uk
bmseem@ic.ac.uk'
author_list:
- family: Smith
given: Rebecca M.
- family: Marroney
given: Natalie
- family: Beattie
given: Jenna
- family: Newdick
given: Abby
- family: Tahtis
given: Vassilios
- family: Burgess
given: Caroline
- family: Marsden
given: Jonathan
- family: Seemungal
given: Barry M.
da: '2023-09-28'
doi: 10.1186/s40814-020-00669-z
eissn: 2055-5784
files: []
journal: PILOT AND FEASIBILITY STUDIES
keywords: 'Feasibility study; Traumatic brain injury; Benign paroxysmal positional
vertigo; Rehabilitation'
keywords-plus: 'QUALITY-OF-LIFE; CLINICAL-TRIAL; RISK-FACTORS; DIZZINESS; FALLS; SCALE;
DISABILITY; COMMUNITY; VALIDITY; OUTCOMES'
language: English
number: '1'
number-of-cited-references: '58'
orcid-numbers: 'Smith, Rebecca/0000-0003-2628-9861
Seemungal, Barry/0000-0002-6578-0904'
papis_id: 967a445ccd2525f24d245b7777c146ba
ref: Smith2020mixedmethods
times-cited: '1'
title: A mixed methods randomised feasibility trial investigating the management of
benign paroxysmal positional vertigo in acute traumatic brain injury
2023-10-01 08:15:07 +00:00
type: article
2023-09-28 14:46:10 +00:00
unique-id: WOS:000729238200130
usage-count-last-180-days: '0'
usage-count-since-2013: '0'
volume: '6'
web-of-science-categories: Medicine, Research \& Experimental
year: '2020'