wow-inequalities/02-data/intermediate/wos_sample/96b94a73b8993899176cbb1e16f3fb63-akakpo-patrick-kafu/info.yaml

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2023-09-28 14:46:10 +00:00
abstract: 'BackgroundFor women living with HIV (WLHIV), the burden of persistent
HPV infection, cervical pre-cancerous lesions and cancer have been
demonstrated to be higher than among HIV-negative women. As Ghana and
other lower-middle-income countries (LMIC) work toward developing
national cervical cancer programmes, it is essential that local
scientific evidence be provided to guide policy decisions, especially
for such special populations. The objective of this study was to
determine the distribution of high-risk HPV genotype and related factors
among WLHIV and its implication for the prevention of cervical cancer
prevention efforts.MethodsA cross-sectional study was conducted at the
Cape Coast Teaching Hospital in Ghana. WLHIV, aged 25-65 years, who met
the eligibility criteria were recruited through a simple random sampling
method. An interviewer-administered questionnaire was used to gather
socio-demographic, behavioural, clinical and other pertinent
information. The AmpFire HPV detection system (Atila BioSystem, Mointain
View, CA was used to detect 15 high-risk HPV genotypes from
self-collected cervico-vaginal samples. The data collected were exported
to STATA 16.0 for statistical analysis.ResultsIn all, 330 study
participants, with mean age of 47.2 years (SD +/- 10.7), were involved.
Most (69.1\%, n = 188/272) had HIV viral loads < 1000 copies/ml and
41.2\% (n = 136) had ever heard of cervical screening. The overall
hr-HPV prevalence was 42.7\% (n = 141, 95\% CI 37.4-48.1) and the five
commonest hr-HPV types among screen positives were HPV59 (50.4\%), HPV18
(30.5\%), HPV35 (26.2\%), HPV58 (17\%) and HPV45 (14.9\%). Most infected
women (60.3\%, n = 85) had multiple hr-HPV infections, with about 57.4\%
(n = 81) having 2-5 h-HPV types, while 2.8\% (n = 4) had more than five
hr-HPV types. A total of 37.6\% (n = 53) had HPV16 and/or18, while
66.0\% (n = 93) had the hr-HPV genotypes covered by the nonavalent
vaccine. Women with HIV viral load >= 1000copies/ml (AOR = 5.58, 95\% CI
2.89-10.78, p < 0.001) had a higher likelihood of being
co-infected.ConclusionThis study found out that the prevalence of hr-HPV
still remains high in women with HIV, with a notable occurrence of
multiple infections and infection with genotypes 16 and/or18.
Additionally, an association was established between hr-HPV and
infection HIV viral load.. Therefore, comprehensive HIV care for these
women should include awareness of cervical cancer, consideration of
vaccination and implementation of screening and follow-up protocols.
National programmes in LMIC, such as Ghana, should consider using
HPV-based screen-triage-treat approach with partial genotyping.'
affiliation: 'Obiri-Yeboah, D (Corresponding Author), Cape Coast Teaching Hosp, Publ
Hlth Unit, Cape Coast, Ghana.
Obiri-Yeboah, D (Corresponding Author), Univ Cape Coast, Sch Med Sci, Dept Microbiol
\& Immunol, Cape Coast, Ghana.
Akakpo, Patrick Kafui; Derkyi-Kwarteng, Leonard, Univ Cape Coast, Sch Med Sci, Dept
Anat Pathol, Cape Coast, Ghana.
Ken-Amoah, Sebastian, Univ Cape Coast, Sch Med Sci, Dept Obstet \& Gynaecol, Cape
Coast, Ghana.
Enyan, Nancy Innocentia Ebu, Univ Cape Coast, Sch Nursing \& Midwifery, Dept Adult
Hlth, Cape Coast, Ghana.
Agyare, Elizabeth; Baidoo, Ibrahim; Obiri-Yeboah, Dorcas, Cape Coast Teaching Hosp,
Publ Hlth Unit, Cape Coast, Ghana.
Agyare, Elizabeth; Salia, Emmanuel; Obiri-Yeboah, Dorcas, Univ Cape Coast, Sch Med
Sci, Dept Microbiol \& Immunol, Cape Coast, Ghana.
Asare, Matthew, Baylor Univ, Robbins Coll Hlth \& Human Serv, Dept Publ Hlth, Waco,
TX USA.
Adjei, George, Univ Cape Coast, Sch Med Sci, Dept Community Med, Cape Coast, Ghana.
Addo, Stephen Ayisi, Korle Bu, Natl AIDS STIs Control Programme, Accra, Ghana.'
article-number: '33'
author: Akakpo, Patrick Kafui and Ken-Amoah, Sebastian and Enyan, Nancy Innocentia
Ebu and Agyare, Elizabeth and Salia, Emmanuel and Baidoo, Ibrahim and Derkyi-Kwarteng,
Leonard and Asare, Matthew and Adjei, George and Addo, Stephen Ayisi and Obiri-Yeboah,
Dorcas
author-email: dobiri-yeboah@ucc.edu.gh
author_list:
- family: Akakpo
given: Patrick Kafui
- family: Ken-Amoah
given: Sebastian
- family: Enyan
given: Nancy Innocentia Ebu
- family: Agyare
given: Elizabeth
- family: Salia
given: Emmanuel
- family: Baidoo
given: Ibrahim
- family: Derkyi-Kwarteng
given: Leonard
- family: Asare
given: Matthew
- family: Adjei
given: George
- family: Addo
given: Stephen Ayisi
- family: Obiri-Yeboah
given: Dorcas
da: '2023-09-28'
doi: 10.1186/s13027-023-00513-y
files: []
issn: 1750-9378
journal: INFECTIOUS AGENTS AND CANCER
keywords: HPV; HIV; Ghana; Cervical cancer; Screening; Resource-limited settings
keywords-plus: 'INTRAEPITHELIAL NEOPLASIA; INFECTION; PREVALENCE; WORLDWIDE; MORTALITY;
KNOWLEDGE; BARRIERS; AFRICA'
language: English
month: MAY 26
number: '1'
number-of-cited-references: '72'
orcid-numbers: 'Salia, Emmanuel/0009-0009-8607-9410
Agyare, Elizabeth/0000-0002-1696-474X'
papis_id: 64f06d5d41e732397a565a8d775c5db4
ref: Akakpo2023highriskhuman
times-cited: '0'
title: High-risk human papillomavirus genotype distribution among women living with
HIV; implication for cervical cancer prevention in a resource limited setting
2023-10-01 08:15:07 +00:00
type: article
2023-09-28 14:46:10 +00:00
unique-id: WOS:000994189000001
usage-count-last-180-days: '0'
usage-count-since-2013: '0'
volume: '18'
web-of-science-categories: Oncology; Immunology
year: '2023'