2023-09-28 14:46:10 +00:00
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abstract: 'Background Ewing Sarcoma (ES) is an aggressive tumor affecting
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adolescents and young adults. Prior studies investigated the association
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between rurality and outcomes, although there is a paucity of literature
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focusing on ES. Objective This study aims to determine whether ES
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patients in rural areas are subject to adverse outcomes. Methods This
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study utilized the Surveillance, Epidemiology, and End Results (SEER)
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database. A Poisson regression model was used with controls for race,
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sex, median county income, and age to determine the association between
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rurality and tumor size. A multivariate Cox Proportional Hazard Model
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was utilized, controlling for age, race, gender, income, and tumor size.
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Results There were 868 patients eligible for analysis, with a mean age
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of 14.14 years. Of these patients, 97 lived in rural counties (11.18\%).
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Metropolitan areas had a 9.50\% smaller tumor size (p<0.0001), compared
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to non-metropolitan counties. Patients of Black race had a 14.32\%
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larger tumor size (p<0.0001), and male sex was associated with a 15.34\%
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larger tumor size (p<0.0001). The Cox Proportional Hazard model
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estimated that metropolitan areas had a 36\% lower risk of death over
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time, compared to non-metropolitan areas (HR: 0.64, p <= 0.04).
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Conclusion Patients in metropolitan areas had a smaller tumor size at
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time of diagnosis and had a more favorable survival rate for
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cancer-specific mortality compared to patients residing in rural areas.
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Further work is needed to examine interventions to reduce this
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discrepancy and investigate the effect of extremely rural and urban
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settings and why racial disparities occur.'
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author: Alsoof, Daniel and Kasthuri, Viknesh and Homer, Alexander and Glueck, Jacob
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and McDonald, Christopher L. and Kuris, Eren O. and Daniels, Alan H.
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author_list:
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- family: Alsoof
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given: Daniel
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- family: Kasthuri
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given: Viknesh
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- family: Homer
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given: Alexander
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- family: Glueck
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given: Jacob
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- family: McDonald
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given: Christopher L.
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- family: Kuris
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given: Eren O.
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- family: Daniels
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given: Alan H.
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da: '2023-09-28'
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doi: 10.52965/001c.74118
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eissn: 2035-8164
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files: []
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issn: 2035-8237
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journal: ORTHOPEDIC REVIEWS
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keywords-plus: RACIAL DISPARITIES; HOSPITAL VOLUME; CHEMOTHERAPY; ACCESS; CARE
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language: English
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number-of-cited-references: '27'
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papis_id: d0a5dd860c709e4af1d35900ae091773
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ref: Alsoof2023countyrurality
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times-cited: '0'
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title: County Rurality is Associated with Increased Tumor Size and Decreased Survival
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in Patients with Ewing Sarcoma
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2023-10-01 08:15:07 +00:00
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type: article
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2023-09-28 14:46:10 +00:00
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unique-id: WOS:000998624200003
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usage-count-last-180-days: '0'
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usage-count-since-2013: '0'
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volume: '15'
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web-of-science-categories: Orthopedics
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year: '2023'
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