2023-09-28 14:46:10 +00:00
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abstract: 'Background: Anti-cancer cytotoxic treatments like platinum-derived
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compounds often show low therapeutic efficacy, high-risk side effects
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and resistance. Hence, targeted treatments designed to attack only
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tumour cells avoiding these harmful side effects are highly needed in
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clinical practice. Due to this, precision oncology has arisen as an
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approach to specifically target alterations present only in cancer
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cells, minimising side effects for patients. It involves the use of
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molecular biomarkers present in each kind of tumour for diagnosis,
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prognosis and treatment. Since these biomarkers are specific for each
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cancer type, physicians use them to stratify, diagnose or take the best
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therapeutic options for each patient depending on the features of the
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specific tumour.
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Aim: This review aims to describe the current situation, limitations,
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advantages and perspectives about precision oncology in Latin America.
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Main body: For many years, many biomarkers have been used in a clinical
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setting in developed countries. However, in Latin American countries,
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their broad application has not been affordable partially due to
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financial and technical limitations associated with precarious health
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systems and poor access of low-income populations to quality health
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care. Furthermore, the genetic mixture in Latin American populations
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could generate differences in treatment responses from one population to
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another (pharmacoethnicity) and this should be evaluated before
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establishing precision therapy in particular populations. Some research
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groups in the region have done a lot of work in this field and these
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data should be taken as a starting point to establish networks oriented
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to finding clinically useful cancer biomarkers in Latin American
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populations.
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Conclusion: Latin America must create policies allowing excluded
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populations to gain access to health systems and next generation
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anti-cancer drugs, i.e. high-cost targeted therapies to improve
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survival. Also, cancer clinical research must be oriented to establish
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cancer biomarkers adapted to specific populations with different
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ethnicity, allowing the improvement of patient outcomes.'
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affiliation: 'Orue, A (Corresponding Author), IVIC, Ctr Microbiol, Tumor Cell Biol
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Lab, Caracas 1020A, Venezuela.
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Calderon-Auaricio, Ali; Orue, Andrea, IVIC, Ctr Microbiol, Tumor Cell Biol Lab,
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Caracas 1020A, Venezuela.'
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article-number: '920'
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author: Calderon-Auaricio, Ali and Orue, Andrea
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author-email: andreaorue@gmail.com
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author_list:
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- family: Calderon-Auaricio
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given: Ali
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- family: Orue
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given: Andrea
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da: '2023-09-28'
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doi: 10.3332/ecancer.2019.920
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files: []
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issn: 1754-6605
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journal: ECANCERMEDICALSCIENCE
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keywords: 'precision oncology; biomarkers; cancer; targeted therapy; access to
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health care; Latin America'
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keywords-plus: 'CELL LUNG-CANCER; ANDROGEN RECEPTOR; PERSONALIZED MEDICINE; OPEN-LABEL;
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METHYLATION; EPIGENOMICS; MUTATIONS; THERAPY; DRUGS; EGFR'
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language: English
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month: APR 3
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number-of-cited-references: '78'
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orcid-numbers: Calderon-Aparicio, Ali/0000-0003-0656-1434
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papis_id: fc9d7da5e3f031b464597b9888d132ba
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ref: Calderonauaricio2019precisiononcology
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times-cited: '7'
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title: 'Precision oncology in Latin America: current situation, challenges and perspectives'
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2023-10-01 08:15:07 +00:00
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type: article
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2023-09-28 14:46:10 +00:00
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unique-id: WOS:000464006000001
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usage-count-last-180-days: '0'
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usage-count-since-2013: '2'
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volume: '13'
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web-of-science-categories: Oncology
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year: '2019'
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