2023-09-28 14:46:10 +00:00
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abstract: 'Background: After a first episode of psychosis, cognitive impairments
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present an important barrier to successful (re-)entry into work and
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education. We assessed whether cognitive remediation (CR) as an add-on
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to Individual Placement and Support (IPS) can improve participation in
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regular employment and education.
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Method: Participants with early psychosis (N = 73) were randomly
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assigned to receive IPS supplemented with computerized CR, or IPS plus
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an active control intervention (computer games). The primary outcome was
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the number of hours spent in competitive employment or regular
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education, which was assessed every month during the 18-month study
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period. Secondary outcomes included employment rate, cognitive
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functioning, mental health (assessed at baseline, 6 and 18 months), and
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job duration (assessed after 18 months). Both patients and assessors
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were blind to treatment.
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Results: Participants receiving IPS + CR showed greater improvement of
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competitive employment over time in terms of hours worked (during
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follow-up period: 38.5 vs. 19.6 h, B = 2.94; Wald chi(2) = 5.39; P =
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.02) and employment rate (at T2: 62.1\% vs. 25.9\%, chi 2 = 7.39; df =
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1; P = .008), compared with the IPS + control group, particularly in the
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longer term. The number of hours spent in regular education was lower in
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the IPS + CR group, with more participants having ended education for a
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positive reason. There was a significant beneficial effect of adjunctive
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CR for executive functioning, subjective cognitive functioning, and
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empowerment.
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Conclusions: Augmenting IPS with CR has a significant impact on
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competitive employment in people with early psychosis, with beneficial
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effects being more pronounced after 18 months.'
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affiliation: 'van Duin, D (Corresponding Author), Ctr Expertise Severe Mental Illness,
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Da Costakade 45,POB 1203, NL-3500 BE Utrecht, Netherlands.
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van Duin, Danielle; de Winter, Lars; van Weeghel, Jaap, Phrenos Ctr Expertise, Utrecht,
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Netherlands.
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van Duin, Danielle; Kroon, Hans, Trimbos Inst, Tilburg, Netherlands.
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van Duin, Danielle; Kroon, Hans; van Weeghel, Jaap, Tilburg Univ, Tilburg Sch Social
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\& Behav Sci, Tranzo, Tilburg, Netherlands.
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Veling, Wim, Univ Groningen, Groningen, Netherlands.
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Veling, Wim, Univ Med Ctr Groningen, Groningen, Netherlands.'
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author: van Duin, Danielle and de Winter, Lars and Kroon, Hans and Veling, Wim and
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van Weeghel, Jaap
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author-email: dduin@kephrenos.nl
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author_list:
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- family: van Duin
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given: Danielle
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- family: de Winter
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given: Lars
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- family: Kroon
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given: Hans
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- family: Veling
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given: Wim
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- family: van Weeghel
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given: Jaap
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da: '2023-09-28'
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doi: 10.1016/j.schres.2021.07.025
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earlyaccessdate: SEP 2021
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eissn: 1573-2509
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files: []
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issn: 0920-9964
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journal: SCHIZOPHRENIA RESEARCH
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keywords: 'Early psychosis; RCT; Individual placement and support; Add-on;
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Cognitive remediation'
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keywords-plus: 'IMPLEMENTING SUPPORTED EMPLOYMENT; NEGATIVE SYNDROME SCALE; 1ST EPISODE
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PSYCHOSIS; SEVERE MENTAL-ILLNESS; INDIVIDUAL PLACEMENT;
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VOCATIONAL-REHABILITATION; PSYCHOMETRIC PROPERTIES; 1ST-EPISODE
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PSYCHOSIS; SCHIZOPHRENIA; PEOPLE'
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language: English
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month: OCT
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number-of-cited-references: '59'
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orcid-numbers: 'Kroon, Hans/0000-0002-2259-1628
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Veling, Wim/0000-0002-1364-9779'
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pages: 115-122
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papis_id: 149ec35cb8faaeedc613529b9429cf79
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ref: Vanduin2021effectsips
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researcherid-numbers: 'Kroon, Hans/I-5683-2016
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'
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times-cited: '5'
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title: 'Effects of IPS plus cognitive remediation in early psychosis: 18-month functioning
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outcomes of a randomized controlled trial'
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2023-10-01 08:15:07 +00:00
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type: article
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2023-09-28 14:46:10 +00:00
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unique-id: WOS:000701833300018
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usage-count-last-180-days: '1'
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usage-count-since-2013: '3'
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volume: '236'
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web-of-science-categories: Psychiatry
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year: '2021'
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