2023-09-28 14:46:10 +00:00
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abstract: 'Background: Prior work has identified disparities in the quality and
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outcomes of healthcare across socioeconomic subgroups. Medication use
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may be subject to similar disparities.
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Objective: To assess the association between demographic and
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socioeconomic factors (gender, age, race, income, education, and rural
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or urban residence) and appropriateness of medication use.
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Methods: US adults aged >= 45 years (n = 26,798) from the REasons for
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Geographic And Racial Differences in Stroke (REGARDS) study were
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included in the analyses, of which 13,623 participants aged >= 65 years
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(recruited 2003-2007). Potentially inappropriate medication (PIM) use in
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older adults and drug-drug interactions (DDIs) were identified through
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2015 Beers Criteria and clinically significant drug interactions list by
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Ament et al., respectively as measures of medication appropriateness.
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Multivariable logistic regression was used to assess the association of
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disparity parameters with PIM use and DDIs. Interactions between race
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and other disparity variables were investigated.
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Results: Approximately 87\% of the participants aged >= 65 years used at
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least one drug listed in the Beers Criteria, and 3.8\% of all
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participants used two or more drugs with DDIs. Significant gender-race
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interaction across prescription-only drug users revealed that white
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females compared with white males (OR = 1.33, 95\% CI 1.20-1.48) and
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black males compared with white males (OR = 1.60, 95\% CI 1.41-1.82)
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were more likely to receive PIM. Individuals with lower income and
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education also were more likely to use PIM in this sub-group. Females
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were less likely than males (female vs. male: OR = 0.55, 95\% CI
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0.48-0.63) and individuals resided in small rural areas as opposed to
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urban areas (small rural vs. urban: OR = 1.37, 95\% CI 1.07-1.76) were
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more likely to have DDIs.
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Conclusion: Demographic and socioeconomic disparities in PIM use and
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DDIs exist. Future studies should seek to better understand factors
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contributing to the disparities in order to guide development of
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interventions.'
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affiliation: 'Rahman, M; Hansen, R (Corresponding Author), Auburn Univ, Harrison Sch
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Pharm, 2316 Walker Bldg, Auburn, AL 36849 USA.
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Rahman, Motiur; Qian, Jingjing; Garza, Kimberly; Hansen, Richard, Auburn Univ, Harrison
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Sch Pharm, Dept Hlth Outcomes Res \& Policy, Auburn, AL 36849 USA.
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Howard, George, Univ Alabama Birmingham, Dept Biostat, Ryals Sch Publ Hlth, Birmingham,
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AL 35294 USA.
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Abebe, Ash, Auburn Univ, Dept Math \& Stat, Auburn, AL 36849 USA.'
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author: Rahman, Motiur and Howard, George and Qian, Jingjing and Garza, Kimberly and
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Abebe, Ash and Hansen, Richard
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author-email: 'mzr0042@auburn.edu
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rah0019@auburn.edu'
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author_list:
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- family: Rahman
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given: Motiur
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- family: Howard
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given: George
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- family: Qian
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given: Jingjing
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- family: Garza
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given: Kimberly
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- family: Abebe
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given: Ash
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- family: Hansen
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given: Richard
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da: '2023-09-28'
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doi: 10.1016/j.sapharm.2020.02.008
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eissn: 1934-8150
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files: []
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issn: 1551-7411
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journal: RESEARCH IN SOCIAL \& ADMINISTRATIVE PHARMACY
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keywords: 'REGARDS; Potentially inappropriate medication; Drug-drug interaction;
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Socioeconomic disparity'
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keywords-plus: 'POTENTIALLY INAPPROPRIATE MEDICATIONS; UPDATED BEERS CRITERIA;
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HEALTH-CARE; UNITED-STATES; DISEASE; DRUG; MORTALITY; BLACKS; WHITES;
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STOPP'
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language: English
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month: DEC
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number: '12'
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number-of-cited-references: '52'
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orcid-numbers: Abebe, Ash/0000-0001-5759-2383
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pages: 1702-1710
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papis_id: e79570d817b824f7378d5e6ad26164fe
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ref: Rahman2020disparitiesappropria
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researcherid-numbers: Abebe, Ash/C-3681-2014
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times-cited: '4'
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title: 'Disparities in the appropriateness of medication use: Analysis of the REasons
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for Geographic And Racial Differences in Stroke (REGARDS) population-based cohort
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study'
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2023-10-01 08:15:07 +00:00
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type: article
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2023-09-28 14:46:10 +00:00
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unique-id: WOS:000594634100010
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usage-count-last-180-days: '0'
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usage-count-since-2013: '0'
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volume: '16'
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web-of-science-categories: Public, Environmental \& Occupational Health; Pharmacology
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\& Pharmacy
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year: '2020'
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