wow-inequalities/02-data/intermediate/wos_sample/2047f41943b0303715563b5fe0bac81b-thirumurthy-harsha/info.yaml

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2023-09-28 14:46:10 +00:00
abstract: 'Background HIV self-testing can overcome barriers to HIV testing, but
its potential as an HIV prevention strategy for women in sub-Saharan
Africa has not been assessed. We examined whether sustained provision of
self-tests to women promotes testing among sexual partners and reduces
HIV incidence.
Methods We conducted a pair-matched cluster-randomised trial in 66
community clusters in Siaya County, Kenya. Clusters were communities
with a high prevalence of transactional sex, including beach communities
along Lake Victoria and inland communities with hotspots for
transactional sex such as bars and hotels. Within clusters, we recruited
HIV-negative women aged 18 years or older with two or more sexual
partners within the past 4 weeks. In each of the 33 cluster pairs, we
randomly assigned clusters to an intervention and comparison group. In
intervention clusters, we provided participants with multiple self-tests
at regular intervals and encouraged secondary distribution of self-tests
to sexual partners. In comparison clusters, we provided participants
referral cards for facility-based testing. Follow-up visits and HIV
testing occurred at 6-month intervals for up to 24 months. The primary
outcome of HIV incidence among all participants who contributed at least
one HIV test was analysed using discrete-time mixed effects models. This
study is registered with ClinicalTrials.gov, NCT03135067.
Findings Between June 4, 2017, and Aug 31, 2018, we enrolled 2090
participants (1033 in the 33 intervention clusters and 1057 in the 33
comparison clusters). Participants'' median age was 25 years (IQR 22-31)
and 1390 (66.6\%) of 2086 participants reported sex work as an income
source. 1840 participants completed the 18-month follow-up and 570
participants completed the 24-month follow up, which ended on March 25,
2020, with a median follow-up duration of 17.6 months. HIV incidence was
not significantly different between the intervention and comparison
groups (1.2 vs 1.0 per 100 person-years; hazard ratio 12, 95\% CI
0.6-2.3, p=0.64). Social harms related to study participation occurred
in three participants (two in the intervention group and one in the
comparison group).
Interpretation Sustained provision of multiple self-tests to women at
high risk of HIV infection in Kenya enabled secondary distribution of
self-tests to sexual partners but did not affect HIV incidence.
Copyright (C) 2021 Published by Elsevier Ltd. All rights reserved.'
affiliation: 'Thirumurthy, H (Corresponding Author), Univ Penn, Dept Med Eth \& Hlth
Policy, Philadelphia, PA 19004 USA.
Thirumurthy, Harsha; Bair, Elizabeth F.; Marcus, Noora, Univ Penn, Perelman Sch
Med, Dept Med Eth \& Hlth Policy, Philadelphia, PA 19004 USA.
Putt, Mary, Univ Penn, Perelman Sch Med, Dept Biostat \& Epidemiol, Philadelphia,
PA 19004 USA.
Ochwal, Perez; Agot, Kawango, Impact Res \& Dev Org, Kisumu, Kenya.
Maman, Suzanne, Univ N Carolina, Dept Hlth Behav, Chapel Hill, NC 27515 USA.
Napierala, Sue, RTI Int, Womens Global Hlth Imperat, Berkeley, CA USA.'
author: Thirumurthy, Harsha and Bair, Elizabeth F. and Ochwal, Perez and Marcus, Noora
and Putt, Mary and Maman, Suzanne and Napierala, Sue and Agot, Kawango
author-email: hthirumu@upenn.edu
author_list:
- family: Thirumurthy
given: Harsha
- family: Bair
given: Elizabeth F.
- family: Ochwal
given: Perez
- family: Marcus
given: Noora
- family: Putt
given: Mary
- family: Maman
given: Suzanne
- family: Napierala
given: Sue
- family: Agot
given: Kawango
da: '2023-09-28'
files: []
issn: 2352-3018
journal: LANCET HIV
keywords-plus: 'FEMALE SEX WORKERS; NYANZA PROVINCE; TRANSMISSION; MIGRANTS; CLIENTS;
RISKS; CARE'
language: English
month: DEC
number: '12'
number-of-cited-references: '27'
orcid-numbers: Napierala, Sue/0000-0003-1146-8154
pages: E736-E746
papis_id: 3efc37b871b17991064334e62b6a8fb1
ref: Thirumurthy2021effectproviding
times-cited: '4'
title: 'The effect of providing women sustained access to HIV self-tests on male partner
testing, couples testing, and HIV incidence in Kenya: a cluster-randomised trial'
2023-10-01 08:15:07 +00:00
type: article
2023-09-28 14:46:10 +00:00
unique-id: WOS:000725254500006
usage-count-last-180-days: '1'
usage-count-since-2013: '3'
volume: '8'
web-of-science-categories: Immunology; Infectious Diseases
year: '2021'