wow-inequalities/02-data/intermediate/wos_sample/d2e7f24021e326411168f48f6ad0f72c-duffett-mark-and-sw/info.yaml

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2023-09-28 14:46:10 +00:00
abstract: 'Objectives: Clinical research is a complex scientific and social
enterprise. Our objective was to identify strategies that pediatric
critical care trialists consider acceptable, feasible, and effective to
improve the design and conduct randomized controlled trials in pediatric
critical care.
Design: Qualitative descriptive study using semistructured individual
interviews.
Subjects: We interviewed 26 pediatric critical care researchers from
seven countries who have published a randomized controlled trial
(2005-2015). We used purposive sampling to achieve diversity regarding
researcher characteristics and randomized controlled trial
characteristics.
Interventions: None.
Measurements and Main Results: Most participants (24 {[}92\%]) were from
high-income countries, eight (31\%) had published more than one
randomized controlled trial, 17 (65\%) had published a multicenter
randomized controlled trial, and eight (31\%) had published a
multinational randomized controlled trial. An important theme was
building communitiesgroups of individuals with similar interests, shared
experiences, and common values, bound by professional and personal
relationships. Participants described a sense of community as a source
of motivation and encouragement and as a means to larger, more rigorous
trials, increasing researcher and clinician engagement and maintaining
enthusiasm. Strategies to build communities stressed in-person
interactions (both professional and social), capable leadership, and
trust. Another important theme was getting started. Participants
highlighted the importance of formal research training and high-quality
experiential learning through collaboration on other''s projects, guided
by effective mentorship. Also important was working within the
systemensuring academic credit for a range of contributions, not only
for the principal investigator role. The longitudinal notion of building
on success was also underscored as a cross-cutting theme.
Conclusions: Coordinated, deliberate actions to build community and
ensure key training and practical experiences for new investigators may
strengthen the research enterprise in pediatric critical care. These
strategies, potentially in combination with other novel approaches, may
vitalize clinical research in this field.'
affiliation: 'Duffett, M (Corresponding Author), McMaster Univ, Dept Pediat, Hamilton,
ON, Canada.
Duffett, Mark, McMaster Univ, Dept Pediat, Hamilton, ON, Canada.
Swinton, Marilyn; Brouwers, Melissa; Meade, Maureen; Cook, Deborah J., McMaster
Univ, Dept Hlth Res Methods Evidence \& Impact, Hamilton, ON, Canada.
Brouwers, Melissa, McMaster Univ, Dept Oncol, Hamilton, ON, Canada.
Meade, Maureen; Cook, Deborah J., McMaster Univ, Dept Med, Hamilton, ON, Canada.
McMaster Univ, Hamilton, ON, Canada.'
author: Duffett, Mark and Swinton, Marilyn and Brouwers, Melissa and Meade, Maureen
and Cook, Deborah J.
author-email: duffetmc@mcmaster.ca
author_list:
- family: Duffett
given: Mark
- family: Swinton
given: Marilyn
- family: Brouwers
given: Melissa
- family: Meade
given: Maureen
- family: Cook
given: Deborah J.
da: '2023-09-28'
doi: 10.1097/PCC.0000000000001696
eissn: 1947-3893
files: []
issn: 1529-7535
journal: PEDIATRIC CRITICAL CARE MEDICINE
keywords: 'pediatric critical care; qualitative methods; randomized controlled
trials; research methods'
keywords-plus: CLINICAL-TRIALS; PUBLICATION; BARRIERS; QUALITY
language: English
month: NOV
number: '11'
number-of-cited-references: '19'
orcid-numbers: 'Duffett, Mark/0000-0003-1705-5422
Brouwers, Melissa/0000-0002-9699-0269'
pages: E595-E602
papis_id: 7b2eb50dc95fb5d3cdc078016fa47ebf
ref: Duffett2018advancingrandomized
researcherid-numbers: 'Duffett, Mark/B-7524-2019
'
times-cited: '3'
title: 'Advancing Randomized Controlled Trials in Pediatric Critical Care: The Perspectives
of Trialists'
2023-10-01 08:15:07 +00:00
type: article
2023-09-28 14:46:10 +00:00
unique-id: WOS:000448945200005
usage-count-last-180-days: '0'
usage-count-since-2013: '1'
volume: '19'
web-of-science-categories: Critical Care Medicine; Pediatrics
year: '2018'