162 lines
5.4 KiB
YAML
162 lines
5.4 KiB
YAML
abstract: 'BackgroundFor women living with HIV (WLHIV), the burden of persistent
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HPV infection, cervical pre-cancerous lesions and cancer have been
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demonstrated to be higher than among HIV-negative women. As Ghana and
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other lower-middle-income countries (LMIC) work toward developing
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national cervical cancer programmes, it is essential that local
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scientific evidence be provided to guide policy decisions, especially
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for such special populations. The objective of this study was to
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determine the distribution of high-risk HPV genotype and related factors
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among WLHIV and its implication for the prevention of cervical cancer
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prevention efforts.MethodsA cross-sectional study was conducted at the
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Cape Coast Teaching Hospital in Ghana. WLHIV, aged 25-65 years, who met
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the eligibility criteria were recruited through a simple random sampling
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method. An interviewer-administered questionnaire was used to gather
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socio-demographic, behavioural, clinical and other pertinent
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information. The AmpFire HPV detection system (Atila BioSystem, Mointain
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View, CA was used to detect 15 high-risk HPV genotypes from
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self-collected cervico-vaginal samples. The data collected were exported
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to STATA 16.0 for statistical analysis.ResultsIn all, 330 study
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participants, with mean age of 47.2 years (SD +/- 10.7), were involved.
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Most (69.1\%, n = 188/272) had HIV viral loads < 1000 copies/ml and
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41.2\% (n = 136) had ever heard of cervical screening. The overall
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hr-HPV prevalence was 42.7\% (n = 141, 95\% CI 37.4-48.1) and the five
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commonest hr-HPV types among screen positives were HPV59 (50.4\%), HPV18
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(30.5\%), HPV35 (26.2\%), HPV58 (17\%) and HPV45 (14.9\%). Most infected
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women (60.3\%, n = 85) had multiple hr-HPV infections, with about 57.4\%
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(n = 81) having 2-5 h-HPV types, while 2.8\% (n = 4) had more than five
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hr-HPV types. A total of 37.6\% (n = 53) had HPV16 and/or18, while
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66.0\% (n = 93) had the hr-HPV genotypes covered by the nonavalent
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vaccine. Women with HIV viral load >= 1000copies/ml (AOR = 5.58, 95\% CI
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2.89-10.78, p < 0.001) had a higher likelihood of being
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co-infected.ConclusionThis study found out that the prevalence of hr-HPV
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still remains high in women with HIV, with a notable occurrence of
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multiple infections and infection with genotypes 16 and/or18.
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Additionally, an association was established between hr-HPV and
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infection HIV viral load.. Therefore, comprehensive HIV care for these
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women should include awareness of cervical cancer, consideration of
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vaccination and implementation of screening and follow-up protocols.
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National programmes in LMIC, such as Ghana, should consider using
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HPV-based screen-triage-treat approach with partial genotyping.'
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affiliation: 'Obiri-Yeboah, D (Corresponding Author), Cape Coast Teaching Hosp, Publ
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Hlth Unit, Cape Coast, Ghana.
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Obiri-Yeboah, D (Corresponding Author), Univ Cape Coast, Sch Med Sci, Dept Microbiol
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\& Immunol, Cape Coast, Ghana.
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Akakpo, Patrick Kafui; Derkyi-Kwarteng, Leonard, Univ Cape Coast, Sch Med Sci, Dept
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Anat Pathol, Cape Coast, Ghana.
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Ken-Amoah, Sebastian, Univ Cape Coast, Sch Med Sci, Dept Obstet \& Gynaecol, Cape
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Coast, Ghana.
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Enyan, Nancy Innocentia Ebu, Univ Cape Coast, Sch Nursing \& Midwifery, Dept Adult
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Hlth, Cape Coast, Ghana.
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Agyare, Elizabeth; Baidoo, Ibrahim; Obiri-Yeboah, Dorcas, Cape Coast Teaching Hosp,
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Publ Hlth Unit, Cape Coast, Ghana.
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Agyare, Elizabeth; Salia, Emmanuel; Obiri-Yeboah, Dorcas, Univ Cape Coast, Sch Med
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Sci, Dept Microbiol \& Immunol, Cape Coast, Ghana.
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Asare, Matthew, Baylor Univ, Robbins Coll Hlth \& Human Serv, Dept Publ Hlth, Waco,
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TX USA.
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Adjei, George, Univ Cape Coast, Sch Med Sci, Dept Community Med, Cape Coast, Ghana.
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Addo, Stephen Ayisi, Korle Bu, Natl AIDS STIs Control Programme, Accra, Ghana.'
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article-number: '33'
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author: Akakpo, Patrick Kafui and Ken-Amoah, Sebastian and Enyan, Nancy Innocentia
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Ebu and Agyare, Elizabeth and Salia, Emmanuel and Baidoo, Ibrahim and Derkyi-Kwarteng,
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Leonard and Asare, Matthew and Adjei, George and Addo, Stephen Ayisi and Obiri-Yeboah,
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Dorcas
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author-email: dobiri-yeboah@ucc.edu.gh
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author_list:
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- family: Akakpo
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given: Patrick Kafui
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- family: Ken-Amoah
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given: Sebastian
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- family: Enyan
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given: Nancy Innocentia Ebu
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- family: Agyare
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given: Elizabeth
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- family: Salia
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given: Emmanuel
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- family: Baidoo
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given: Ibrahim
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- family: Derkyi-Kwarteng
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given: Leonard
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- family: Asare
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given: Matthew
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- family: Adjei
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given: George
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- family: Addo
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given: Stephen Ayisi
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- family: Obiri-Yeboah
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given: Dorcas
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da: '2023-09-28'
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doi: 10.1186/s13027-023-00513-y
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files: []
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issn: 1750-9378
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journal: INFECTIOUS AGENTS AND CANCER
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keywords: HPV; HIV; Ghana; Cervical cancer; Screening; Resource-limited settings
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keywords-plus: 'INTRAEPITHELIAL NEOPLASIA; INFECTION; PREVALENCE; WORLDWIDE; MORTALITY;
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KNOWLEDGE; BARRIERS; AFRICA'
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language: English
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month: MAY 26
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number: '1'
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number-of-cited-references: '72'
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orcid-numbers: 'Salia, Emmanuel/0009-0009-8607-9410
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Agyare, Elizabeth/0000-0002-1696-474X'
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papis_id: 64f06d5d41e732397a565a8d775c5db4
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ref: Akakpo2023highriskhuman
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times-cited: '0'
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title: High-risk human papillomavirus genotype distribution among women living with
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HIV; implication for cervical cancer prevention in a resource limited setting
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type: article
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unique-id: WOS:000994189000001
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usage-count-last-180-days: '0'
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usage-count-since-2013: '0'
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volume: '18'
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web-of-science-categories: Oncology; Immunology
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year: '2023'
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