abstract: 'Background: Although considerable efforts are directed at developing international guidelines to improve clinical management in low-income settings they appear to influence practice rarely. This study aimed to explore barriers to guideline implementation in the early phase of an intervention study in four district hospitals in Kenya. Methods: We developed a simple interview guide based on a simple characterisation of the intervention informed by review of major theories on barriers to uptake of guidelines. In-depth interviews, non-participatory observation, and informal discussions were then used to explore perceived barriers to guideline introduction and general improvements in paediatric and newborn care. Data were collected four to five months after in-service training in the hospitals. Data were transcribed, themes explored, and revised in two rounds of coding and analysis using NVivo 7 software, subjected to a layered analysis, reviewed, and revised after discussion with four hospital staff who acted as within-hospital facilitators. Results: A total of 29 health workers were interviewed. Ten major themes preventing guideline uptake were identified: incomplete training coverage; inadequacies in local standard setting and leadership; lack of recognition and appreciation of good work; poor communication and teamwork; organizational constraints and limited resources; counterproductive health worker norms; absence of perceived benefits linked to adoption of new practices; difficulties accepting change; lack of motivation; and conflicting attitudes and beliefs. Conclusion: While the barriers identified are broadly similar in theme to those reported from high-income settings, their specific nature often differs. For example, at an institutional level there is an almost complete lack of systems to introduce or reinforce guidelines, poor teamwork across different cadres of health worker, and failure to confront poor practice. At an individual level, lack of interest in the evidence supporting guidelines, feelings that they erode professionalism, and expectations that people should be paid to change practice threaten successful implementation.' affiliation: 'Nzinga, J (Corresponding Author), KEMRI Wellcome Trust Programme, KEMRI Ctr Geog Med Res Coast, POB 43640, Nairobi, Kenya. Nzinga, Jacinta; Mbindyo, Patrick; Mbaabu, Lairumbi; Warira, Ann; English, Mike, KEMRI Wellcome Trust Programme, KEMRI Ctr Geog Med Res Coast, Nairobi, Kenya. English, Mike, Univ Oxford, John Radcliffe Hosp, Dept Paediat, Oxford OX3 9DU, England.' article-number: '44' author: Nzinga, Jacinta and Mbindyo, Patrick and Mbaabu, Lairumbi and Warira, Ann and English, Mike author-email: 'jnzinga@nairobi.kemri-wellcome.org pmbindyo@nairobi.kemri-wellcome.org lmbaabu@nairobi.kemri-wellcome.org awarira@nairobi.kemri-wellcome.org menglish@nairobi.kemri-wellcome.org' author_list: - family: Nzinga given: Jacinta - family: Mbindyo given: Patrick - family: Mbaabu given: Lairumbi - family: Warira given: Ann - family: English given: Mike da: '2023-09-28' doi: 10.1186/1748-5908-4-44 files: [] issn: 1748-5908 journal: IMPLEMENTATION SCIENCE keywords-plus: 'CLINICAL-PRACTICE GUIDELINES; DISTRICT HOSPITALS; CHILDHOOD ILLNESS; PLANNED BEHAVIOR; PEDIATRIC CARE; PUBLIC-SECTOR; NEWBORN CARE; QUALITY; MOTIVATION; MANAGEMENT' language: English month: JUL 23 number-of-cited-references: '34' orcid-numbers: 'Mbindyo, Patrick/0000-0003-0388-0026 Wanjuhi, Anne/0000-0002-4182-6939 English, Michael/0000-0002-7427-0826' papis_id: 3747e16ca0f8c9066ad5bba84785e2d7 ref: Nzinga2009documentingexperienc times-cited: '44' title: Documenting the experiences of health workers expected to implement guidelines during an intervention study in Kenyan hospitals type: article unique-id: WOS:000268892000001 usage-count-last-180-days: '0' usage-count-since-2013: '16' volume: '4' web-of-science-categories: Health Care Sciences \& Services; Health Policy \& Services year: '2009'