abstract: 'Background Indigenous peoples in high income countries are disproportionately affected by Type 2 Diabetes. Socioeconomic disadvantages and inadequate access to appropriate healthcare are important contributors. Objectives This systematic review investigates effective designs of primary care management of Type 2 Diabetes for Indigenous adults in Australia, Canada, New Zealand, and the United States. Primary outcome was change in mean glycated haemoglobin. Secondary outcomes were diabetes-related hospital admission rates, treatment compliance, and change in weight or Body Mass Index. Methods Included studies were critically appraised using Joanna Briggs Institute appraisal checklists. A mixed-method systematic review was undertaken. Quantitative findings were compared by narrative synthesis, meta-aggregation of qualitative factors was performed. Results Seven studies were included. Three reported statistically significant reductions in means HbA1c following their intervention. Seven components of effective interventions were identified. These were: a need to reduce health system barriers to facilitate access to primary care (which the other six components work towards), an essential role for Indigenous community consultation in intervention planning and implementation, a need for primary care programs to account for and adapt to changes with time in barriers to primary care posed by the health system and community members, the key role of community-based health workers, Indigenous empowerment to facilitate community and self-management, benefit of short-intensive programs, and benefit of group-based programs. Conclusions This study synthesises a decade of data from communities with a high burden of Type 2 Diabetes and limited research regarding health system approaches to improve diabetes-related outcomes. Policymakers should consider applying the seven identified components of effective primary care interventions when designing primary care approaches to mitigate the impact of Type 2 Diabetes in Indigenous populations. More robust and culturally appropriate studies of Type 2 Diabetes management in Indigenous groups are needed. Trail registration Registered with PROSPERO (02/04/2021: CRD42021240098).' affiliation: 'Chopra, S (Corresponding Author), Princess Alexandra Hosp, Brisbane, Qld, Australia. Chopra, S (Corresponding Author), Univ Queensland, Brisbane, Qld, Australia. Chopra, Sahil, Princess Alexandra Hosp, Brisbane, Qld, Australia. Chopra, Sahil, Univ Queensland, Brisbane, Qld, Australia. Lahiff, Tahne Joseph, Royal Brisbane \& Womens Hosp, Brisbane, Qld, Australia. Franklin, Richard, James Cook Univ, Coll Publ Hlth Med \& Vet Sci, Townsville, Qld, Australia. Brown, Alex, Australian Natl Univ, Indigenous Genom, Nedlands, WA, Australia. Brown, Alex, Telethon Kids Inst, Nedlands, WA, Australia. Rasalam, Roy, Queensland Hlth, Publ Hlth Med, Townsville, Qld, Australia.' article-number: e0276396 author: Chopra, Sahil and Lahiff, Tahne Joseph and Franklin, Richard and Brown, Alex and Rasalam, Roy author-email: sahilchopra018@gmail.com author_list: - family: Chopra given: Sahil - family: Lahiff given: Tahne Joseph - family: Franklin given: Richard - family: Brown given: Alex - family: Rasalam given: Roy da: '2023-09-28' doi: 10.1371/journal.pone.0276396 files: [] issn: 1932-6203 journal: PLOS ONE keywords-plus: HEALTH-CARE; AMERICAN-INDIANS; CHALLENGES; BARRIERS; CANADA; PEOPLE language: English month: NOV 10 number: '11' number-of-cited-references: '55' orcid-numbers: 'Rasalam, Roy/0000-0002-6822-7936 Franklin, Richard Charles/0000-0003-1864-4552 Brown, Alex/0000-0003-2112-3918 Chopra, Sahil/0000-0002-7835-9131 Lahiff, Tahne/0000-0003-4873-6802' papis_id: 7ef9b78754c8965a3cf7047dc7863500 ref: Chopra2022effectiveprimary researcherid-numbers: 'Rasalam, Roy/N-4558-2017 Brown, Alex D/E-8614-2010 Brown, Allison/JCO-5157-2023 Franklin, Richard Charles/H-1731-2012 ' tags: - review times-cited: '0' title: 'Effective primary care management of type 2 diabetes for indigenous populations: A systematic review' type: article unique-id: WOS:000926098800023 usage-count-last-180-days: '4' usage-count-since-2013: '5' volume: '17' web-of-science-categories: Multidisciplinary Sciences year: '2022'