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Antunes MB, Cohen NA (2007) Mucociliary clearance - a critical upper airway host defense mechanism and methods of assessment. Curr Opin Allergy Clin Immunol 7: 5–10. 4. Riordan JR, Rommens JM, Kerem BS, Alon N, Rozmahel R, et al. (1989) Identification of the Cystic-Fibrosis Gene - Cloning and Characterization of Complementary-Dna. Science 245: 1066–1072. 5. Rommens JM, Iannuzzi MC, Kerem BS, Drumm ML, Melmer G, et al. (1989) Identification of the Cystic-Fibrosis Gene - Chromosome Walking and Jumping. Science 245: 1059–1065. 6. Bobadilla JL, Macek M, Fine JP, Farrell PM (2002) Cystic fibrosis: A worldwide analysis of CFTR mutations - Correlation with incidence data and application to screening. Human Mutation 19: 575–606. 7. Qu BH, Thomas PJ (1996) Alteration of the cystic fibrosis transmembrane conductance regulator folding pathway - Effects of the Delta F508 mutation on the thermodynamic stability and folding yield of NBD1. J Biol Chem 271: 7261–7264.