abstract: 'Certain subgroups of youth are at high risk for depression and elevated depressive symptoms, and experience limited access to quality mental health care. Examples are socioeconomically disadvantaged, racial/ ethnic minority, and sexual minority youth. Research shows that there are efficacious interventions to prevent youth depression and depressive symptoms. These preventive interventions have the potential to play a key role in addressing these mental health disparities by reducing youth risk factors and enhancing protective factors. However, there are comparatively few preventive interventions directed specifically to these vulnerable subgroups, and sample sizes of diverse subgroups in general prevention trials are often too low to assess whether preventive interventions work equally well for vulnerable youth compared to other youth. In this paper, we describe the importance and need for ``scientific equity,{''''} or equality and fairness in the amount of scientific knowledge produced to understand the potential solutions to such health disparities. We highlight possible strategies for promoting scientific equity, including the following: increasing the number of prevention research participants from vulnerable subgroups, conducting more data synthesis analyses and implementation science research, disseminating preventive interventions that are efficacious for vulnerable youth, and increasing the diversity of the prevention science research workforce. These strategies can increase the availability of research evidence to determine the degree to which preventive interventions can help address mental health disparities. Although this paper utilizes the prevention of youth depression as an illustrative case example, the concepts are applicable to other health outcomes for which there are disparities, such as substance use and obesity.' affiliation: 'Perrino, T (Corresponding Author), Univ Miami Miller Sch Med, Dept Publ Hlth Sci, 1120 NW 14th St,1011 R-669, Miami, FL 33136 USA. Perrino, Tatiana; Brincks, Ahnalee; Cruden, Gracelyn; Pantin, Hilda; Prado, Guillermo, Univ Miami Miller Sch Med, Dept Publ Hlth Sci, Miami, FL 33136 USA. Beardslee, William, Harvard Univ, Boston Childrens Hosp, Cambridge, MA 02138 USA. Bernal, Guillermo, Univ Puerto Rico, San Juan, PR 00936 USA. Howe, George, George Washington Univ, Washington, DC USA. Murry, Velma, Vanderbilt Univ, Nashville, TN 37235 USA. Sandler, Irwin, Arizona State Univ, Tempe, AZ USA. Cruden, Gracelyn; Brown, C. Hendricks, Northwestern Univ, Chicago, IL 60611 USA.' author: Perrino, Tatiana and Beardslee, William and Bernal, Guillermo and Brincks, Ahnalee and Cruden, Gracelyn and Howe, George and Murry, Velma and Pantin, Hilda and Prado, Guillermo and Sandler, Irwin and Brown, C. Hendricks author-email: tperrino@med.miami.edu author_list: - family: Perrino given: Tatiana - family: Beardslee given: William - family: Bernal given: Guillermo - family: Brincks given: Ahnalee - family: Cruden given: Gracelyn - family: Howe given: George - family: Murry given: Velma - family: Pantin given: Hilda - family: Prado given: Guillermo - family: Sandler given: Irwin - family: Brown given: C. Hendricks da: '2023-09-28' doi: 10.1007/s11121-014-0518-7 eissn: 1573-6695 files: [] issn: 1389-4986 journal: PREVENTION SCIENCE keywords: 'Scientific equity; Health disparities; Collaborative data synthesis; Depression; Adolescents' keywords-plus: 'MENTAL-HEALTH DISPARITIES; DSM-IV DISORDERS; SUBTHRESHOLD DEPRESSION; CHILDHOOD ADVERSITIES; PSYCHIATRIC-DISORDERS; INTERVENTION RESEARCH; ETHNIC DISPARITIES; SEXUAL MINORITY; CHILDREN; ADOLESCENTS' language: English month: JUL number: '5' number-of-cited-references: '71' orcid-numbers: 'Bernal, Guillermo/0000-0001-8855-1314 Bernal, Guillermo/0000-0001-8855-1314 Brown, C Hendricks/0000-0002-0294-2419' pages: 642-651 papis_id: 6cf89bfe83e165f758f361fb6591c91c ref: Perrino2015scientificequity researcherid-numbers: 'Bernal, Guillermo/O-2513-2019 Brincks, Ahnalee/HLW-8124-2023 Bernal, Guillermo/E-6360-2010 ' times-cited: '31' title: Toward Scientific Equity for the Prevention of Depression and Depressive Symptoms in Vulnerable Youth type: article unique-id: WOS:000355634900002 usage-count-last-180-days: '0' usage-count-since-2013: '13' volume: '16' web-of-science-categories: Public, Environmental \& Occupational Health year: '2015'