abstract: 'Introduction In Manitoba, Canada, there has been an increase in the number of people newly diagnosed with HIV and those not returning for regular HIV care. The COVID-19 pandemic resulted in increased sex and gender disparities in disease risk and mortalities, decreased harm reduction services and reduced access to healthcare. These health crises intersect with increased drug use and drug poisoning deaths, houselessness and other structural and social factors most acutely among historically underserved groups. We aim to explore the social and structural barriers and facilitators to HIV care and harm reduction services experienced by people living with HIV (PLHIV) in Manitoba. Methods and analysis Our study draws on participatory action research design. Guiding the methodological design are the lived experiences of PLHIV. In-depth semi-structured face-to- face interviews and quantitative questionnaires will be conducted with two groups: (1) persons aged >= 18 years living or newly diagnosed with HIV and (2) service providers who work with PLHIV. Data collection will include sex, gender, sociodemographic information, income and housing, experiences with the criminal justice system, sexual practices, substance use practices and harm reduction access, experiences with violence and support, HIV care journey (since diagnosis until present), childhood trauma and a decision-making questionnaire. Data will be analysed intersectionally, employing grounded theory for thematic analysis, sex-based and gender-based analysis and social determinants of health and syndemic framework to understand the experiences of PLHIV in Manitoba. Ethics and dissemination We received approval from the University of Manitoba Health Ethics Research Board (HS25572; H2022:218), First Nations Health and Social Secretariat of Manitoba, Nine Circles Community Health Centre, Shared Health Manitoba (SH2022:194) and 7th Street Health Access Centre. Findings will be disseminated using community-focused knowledge translation strategies identified by participants, peers, community members and organisations, and reported in conferences, peer-reviewed journals and a website (www. alltogether4ideas.org).' affiliation: 'Rueda, ZV (Corresponding Author), Univ Manitoba, Max Rady Coll Med, Rady Fac Hlth Sci, Dept Med Microbiol \& Infect Dis, Winnipeg, MB, Canada. Rueda, Zulma Vanessa; Sobie, Cheryl; Villacis, Enrique; Bullard, Jared; Keynan, Yoav, Univ Manitoba, Max Rady Coll Med, Rady Fac Hlth Sci, Dept Med Microbiol \& Infect Dis, Winnipeg, MB, Canada. Haworth-Brockman, Margaret; Keynan, Yoav, Univ Manitoba, Natl Collaborating Ctr Infect Dis, Winnipeg, MB, Canada. Haworth-Brockman, Margaret; Sanguins, Julianne; Keynan, Yoav, Univ Manitoba, Rady Fac Hlth Sci, Dept Community Hlth Sci, Winnipeg, MB, Canada. Larcombe, Linda; MacKenzie, Lauren; Kasper, Ken; Keynan, Yoav, Univ Manitoba, Max Rady Coll Med, Rady Fac Hlth Sci, Dept Internal Med, Winnipeg, MB, Canada. Maier, Katharina, Univ Winnipeg, Criminal Justice, Winnipeg, MB, Canada. Deering, Kathleen; Krusi, Andrea, Univ British Columbia, Dept Med, Vancouver, BC, Canada. Deering, Kathleen; Krusi, Andrea, Univ British Columbia, Ctr Gender \& Sexual Hlth Equ, Vancouver, BC, Canada. Templeton, Kimberly; MacKenzie, Lauren; Ireland, Laurie; Kasper, Ken, Manitoba HIV Program, Winnipeg, MB, Canada. Templeton, Kimberly; Ireland, Laurie; Payne, Michael, Nine Circles Community Hlth Ctr, Winnipeg, MB, Canada. Bullard, Jared, Shared Hlth, Cadham Prov Lab, Winnipeg, MB, Canada. Pick, Neora, Univ British Columbia, Div Infect Dis, Vancouver, BC, Canada. Myran, Tara, Univ Winnipeg, Indigenous Dev, Winnipeg, MB, Canada. Meyers, Adrienne, Indigenous Serv Canada, Lab Integrat, Off Populat \& Publ Hlth, Winnipeg, MB, Canada.' author: Rueda, Zulma Vanessa and Haworth-Brockman, Margaret and Sobie, Cheryl and Villacis, Enrique and Larcombe, Linda and Maier, Katharina and Deering, Kathleen and Sanguins, Julianne and Templeton, Kimberly and MacKenzie, Lauren and Ireland, Laurie and Kasper, Ken and Payne, Michael and Bullard, Jared and Krusi, Andrea and Pick, Neora and Myran, Tara and Meyers, Adrienne and Keynan, Yoav author-email: zulma.rueda@umanitoba.ca author_list: - family: Rueda given: Zulma Vanessa - family: Haworth-Brockman given: Margaret - family: Sobie given: Cheryl - family: Villacis given: Enrique - family: Larcombe given: Linda - family: Maier given: Katharina - family: Deering given: Kathleen - family: Sanguins given: Julianne - family: Templeton given: Kimberly - family: MacKenzie given: Lauren - family: Ireland given: Laurie - family: Kasper given: Ken - family: Payne given: Michael - family: Bullard given: Jared - family: Krusi given: Andrea - family: Pick given: Neora - family: Myran given: Tara - family: Meyers given: Adrienne - family: Keynan given: Yoav da: '2023-09-28' doi: 10.1136/bmjopen-2022-067813 files: [] issn: 2044-6055 journal: BMJ OPEN keywords: 'COVID-19; HIV \& AIDS; qualitative research; sexual and gender minorities; substance misuse; health services accessibility' keywords-plus: INTERVENTIONS; HIV/AIDS; TRAUMA language: English month: AUG number: '8' number-of-cited-references: '51' orcid-numbers: 'Rueda, Zulma Vanessa/0000-0001-6342-1812 Villacis, Enrique/0000-0003-0033-9410' papis_id: 02c9c50cecf50bdee3b8f4722ff1b0f3 ref: Rueda2023socialstructural times-cited: '0' title: 'Social and structural barriers and facilitators to HIV healthcare and harm reduction services for people experiencing syndemics in Manitoba: study protocol' type: article unique-id: WOS:001045474900018 usage-count-last-180-days: '0' usage-count-since-2013: '0' volume: '13' web-of-science-categories: Medicine, General \& Internal year: '2023'