abstract: 'Background: Using information technology for medication management is an

  opportunity to help physicians to improve the quality of their

  documentation and communication and ultimately to improve patient care

  and patient safety. Physician education is necessary to take full

  advantage of information technology systems. In this trial, we seek to

  determine the effectiveness of an intensive educational intervention

  compared with the standard approach in improving information

  technology-mediated medication management and in reducing potential

  adverse drug events in the outpatient clinic.

  Methods/Design: We are conducting a multicenter, cluster randomized

  controlled trial. The participants are specialists and residents working

  in the outpatient clinic of internal medicine, cardiology, pulmonology,

  geriatrics, gastroenterology and rheumatology. The intensive educational

  intervention is composed of a small-group session and e-learning. The

  primary outcome is discrepancies between registered medication (by

  physicians) and actually used medication (by patients). The key

  secondary outcomes are potential adverse events caused by missed

  drug-drug interactions. The primary and key secondary endpoints are

  being assessed shortly after the educational intervention is completed.

  Sample size will be calculated to ensure sufficient power. A sample size

  of 40 physicians per group and 20 patients per physician will ensure a

  power of >90 \%, which means we will need a total of 80 physicians and

  1,600 patients.

  Discussion: We performed an exploratory trial wherein we tested the

  recruitment process, e-learning, time schedule, and methods for data

  collection, data management and data analysis. Accordingly, we refined

  the processes and content: the recruitment strategy was intensified,

  extra measures were taken to facilitate smooth conductance of the

  e-learning and parts were made optional. First versions of the

  procedures for data collection were determined. Data entry and analysis

  was further standardized by using the G-standard database in the

  telephone questionnaire.'
affiliation: 'van Stiphout, F (Corresponding Author), Univ Med Ctr Utrecht, Dept Internal
  Med, Hijmans van den Berghgebouw Kamer 4-21, NL-3508 GA Utrecht, Netherlands.

  van Stiphout, F.; ter Braak, E. W. M. T., Univ Med Ctr Utrecht, Dept Internal Med,
  NL-3508 GA Utrecht, Netherlands.

  van Stiphout, F.; ter Braak, E. W. M. T., Univ Med Ctr Utrecht, Ctr Res \& Dev Educ,
  NL-3508 GA Utrecht, Netherlands.

  Zwart-van Rijkom, J. E. F.; Egberts, A. C. G., Univ Med Ctr Utrecht, Dept Clin Pharm,
  NL-3584 CX Utrecht, Netherlands.

  Zwart-van Rijkom, J. E. F.; Egberts, A. C. G., Univ Utrecht, Fac Sci, Utrecht Inst
  Pharmaceut Sci, Div Pharmacoepidemiol \& Clin Pharmacol, NL-3508 TB Utrecht, Netherlands.

  Aarts, J. E. C. M., Erasmus Univ, Inst Hlth Policy \& Management, Rotterdam, Netherlands.

  Aarts, J. E. C. M., SUNY Buffalo, Sch Med \& Biomed Sci, Dept Biomed Informat, Buffalo,
  NY 14203 USA.

  Koffijberg, H., Univ Med Ctr Utrecht, Julius Ctr, Dept Hlth Technol Assessment,
  NL-3508 GA Utrecht, Netherlands.

  Klarenbeek-deJonge, E.; Krulder, M., Univ Utrecht, Fac Med, NL-3584 CG Utrecht,
  Netherlands.

  Roes, K. C. B., Univ Med Ctr Utrecht, Dept Qual \& Patient Safety, NL-3508 GA Utrecht,
  Netherlands.'
article-number: '223'
author: van Stiphout, F. and Zwart-van Rijkom, J. E. F. and Aarts, J. E. C. M. and
  Koffijberg, H. and Klarenbeek-deJonge, E. and Krulder, M. and Roes, K. C. B. and
  Egberts, A. C. G. and ter Braak, E. W. M. T.
author-email: f.vanstiphout@umcutrecht.nl
author_list:
- family: van Stiphout
  given: F.
- family: Zwart-van Rijkom
  given: J. E. F.
- family: Aarts
  given: J. E. C. M.
- family: Koffijberg
  given: H.
- family: Klarenbeek-deJonge
  given: E.
- family: Krulder
  given: M.
- family: Roes
  given: K. C. B.
- family: Egberts
  given: A. C. G.
- family: ter Braak
  given: E. W. M. T.
da: '2023-09-28'
doi: 10.1186/s13063-015-0744-8
eissn: 1745-6215
files: []
journal: TRIALS
keywords: 'Continuing medical education; CPOE; Information technology; Meaningful

  use; Medication management; Physicians'
keywords-plus: ADVERSE DRUG EVENTS
language: English
month: MAY 22
number-of-cited-references: '19'
orcid-numbers: 'Egberts, Toine/0000-0003-1758-7779

  Aarts, Jos/0000-0002-9787-688X

  Roes, Kit/0000-0002-6775-1963

  Egberts, Toine/0000-0003-1758-7779

  Koffijberg, Hendrik/0000-0002-1753-0652'
papis_id: e135fa57e714732ef7b69bb02db876b1
ref: Vanstiphout2015meducatetrial
researcherid-numbers: 'Egberts, Toine/A-6625-2012

  Aarts, Jos/B-4456-2008

  Roes, Kit/AAC-4093-2019

  Egberts, Toine/K-4579-2019

  '
times-cited: '3'
title: 'MEDUCATE trial: effectiveness of an intensive EDUCATional intervention for
  IT-mediated MEDication management in the outpatient clinic - study protocol for
  a cluster randomized controlled trial'
type: article
unique-id: WOS:000355304300001
usage-count-last-180-days: '0'
usage-count-since-2013: '3'
volume: '16'
web-of-science-categories: Medicine, Research \& Experimental
year: '2015'