abstract: 'Background: District health managers play a key role in the effectiveness of decentralized health systems in low- and middle-income countries. Inadequate management and leadership skills often hamper their ability to improve quality of care and effectiveness of health service delivery. Nevertheless, significant investments have been made in capacity-building programmes based on site-based training, mentoring, and operational research. This systematic review aims to review the effectiveness of site-based training, mentoring, and operational research (or action research) on the improvement of district health system management and leadership. Our secondary objectives are to assess whether variations in composition or intensity of the intervention influence its effectiveness and to identify enabling and constraining contexts and underlying mechanisms. Methods: We will search the following databases: MEDLINE, PsycInfo, Cochrane Library, CRD database (DARE), Cochrane Effective Practice and Organisation of Care (EPOC) group, ISI Web of Science, Health Evidence. org, PDQ-Evidence, ERIC, EMBASE, and TRIP. Complementary search will be performed (hand-searching journals and citation and reference tracking). Studies that meet the following PICO (Population, Intervention, Comparison, Outcome) criteria will be included: P: professionals working at district health management level; I: site-based training with or without mentoring, or operational research; C: normal institutional arrangements; and O: district health management functions. We will include cluster randomized controlled trials, controlled before-and-after studies, interrupted time series analysis, quasi-experimental designs, and cohort and longitudinal studies. Qualitative research will be included to contextualize findings and identify barriers and facilitators. Primary outcomes that will be reported are district health management and leadership functions. We will assess risk of bias with the Cochrane Collaboration''s tools for randomized controlled trials (RCT) and non RCT studies and Critical Appraisal Skills Programme checklists for qualitative studies. We will assess strength of recommendations with the GRADE tool for quantitative studies, and the CERQual approach for qualitative studies. Synthesis of quantitative studies will be performed through meta-analysis when appropriate. Best fit framework synthesis will be used to synthesize qualitative studies. Discussion: This protocol paper describes a systematic review assessing the effectiveness of site-based training (with or without mentoring programmes or operational research) on the improvement of district health system management and leadership.' affiliation: 'Belrhiti, Z (Corresponding Author), Natl Sch Publ Hlth, Dept Management \& Econ, Rabat, Morocco. Belrhiti, Zakaria, Natl Sch Publ Hlth, Dept Management \& Econ, Rabat, Morocco. Booth, Andrew, Univ Sheffield, Sch Hlth \& Related Res ScHARR, Sheffield, S Yorkshire, England. Marchal, Bruno, Inst Trop Med, Hlth Serv Org Unit, Antwerp, Belgium. Verstraeten, Roosmarijn, Inst Trop Med, Nutr \& Child Hlth Unit, Antwerp, Belgium.' article-number: '70' author: Belrhiti, Zakaria and Booth, Andrew and Marchal, Bruno and Verstraeten, Roosmarijn author-email: drbelrhiti@gmail.com author_list: - family: Belrhiti given: Zakaria - family: Booth given: Andrew - family: Marchal given: Bruno - family: Verstraeten given: Roosmarijn da: '2023-09-28' doi: 10.1186/s13643-016-0239-z eissn: 2046-4053 files: [] journal: SYSTEMATIC REVIEWS keywords: 'Site-based training; Mentoring; Operational research; Best fit framework synthesis; District health; Management; Leadership; Low- and middle-income countries' keywords-plus: QUALITY; DECENTRALIZATION; CAPACITY language: English number-of-cited-references: '38' orcid-numbers: 'Booth, Andrew/0000-0003-4808-3880 Belrhiti, Zakaria/0000-0002-0115-682X ' papis_id: e31ea1c596a3e446fcb38cc5770950dd ref: Belrhiti2016whatextent researcherid-numbers: 'Booth, Andrew/A-7872-2008 Belrhiti, Zakaria/G-4532-2016 Marchal, Bruno/ACO-6522-2022' tags: - review times-cited: '10' title: 'To what extent do site-based training, mentoring, and operational research improve district health system management and leadership in low- and middle-income countries: a systematic review protocol' type: article unique-id: WOS:000453148200069 usage-count-last-180-days: '0' usage-count-since-2013: '4' volume: '5' web-of-science-categories: Medicine, General \& Internal year: '2016'