abstract: 'The Multiple Sclerosis Work Difficulties Questionnaire-23 (MSWDQ-23) is a self-report instrument developed to assess barriers faced by People with Multiple Sclerosis (PwMS) in the workplace. The aim of this study was to explore the psychometric properties of the Greek version of the MSWDQ-23. The study sample consisted of 196 PwMS, all currently working in part- or full-time jobs. Participants underwent clinical examination and cognitive screening with the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) and completed self-report measures of fatigue, psychological functioning, and quality of life, along with the MSWDQ-23 questionnaire. Confirmatory Factor Analysis (CFA) was performed, and goodness-of-fit measures were used to evaluate construct validity. Convergent validity was checked by correlating MSWDQ-23 scores with study measures. Cronbach''s alpha value was produced to assess internal consistency. CFA yielded a model with a fair fit confirming the three-factor structure of the instrument. Higher work difficulties were associated with higher Expanded Disability Status Scale (EDSS) scores, poorer cognitive function, more fatigue, stress, anxiety, and depression, and poorer health status, supporting the convergent validity of MSWDQ-23. Internal consistency (Cronbach''s alpha = 0.94) and test-retest reliability (ICC = 0.996, 95\%, CI = 0.990-0.998) were excellent. The Greek MSWDQ-23 can be considered a valid patient-reported outcome measure and can be used in interventions aiming to improve the vocational status of PwMS.' affiliation: 'Bakirtzis, C (Corresponding Author), Aristotle Univ Thessaloniki, Multiple Sclerosis Ctr, Dept Neurol 2, GR-54124 Thessaloniki, Greece. Bakirtzis, Christos; Nteli, Elli; Boziki, Marina Kleopatra; Grigoriadis, Nikolaos, Aristotle Univ Thessaloniki, Multiple Sclerosis Ctr, Dept Neurol 2, GR-54124 Thessaloniki, Greece. Artemiadis, Artemios, Univ Cyprus, Fac Med, CY-2029 Nicosia, Cyprus. Karakasi, Maria-Valeria, AHEPA Univ, Univ Dept Psychiat 3, Gen Hosp, GR-54124 Thessaloniki, Greece. Honan, Cynthia, Univ Tasmania, Coll Hlth \& Med, Sch Psychol Sci, Launceston, Tas 7250, Australia. Messinis, Lambros, Univ Hosp Patras, Neuropsychol Sect, GR-26504 Patras, Greece. Nasios, Grigorios, Univ Ioannina, Dept Speech \& Language Therapy, GR-45110 Ioannina, Greece. Dardiotis, Efthimios, Univ Thessaly, Dept Neurol, GR-41500 Larisa, Greece.' article-number: '897' author: Bakirtzis, Christos and Artemiadis, Artemios and Nteli, Elli and Boziki, Marina Kleopatra and Karakasi, Maria-Valeria and Honan, Cynthia and Messinis, Lambros and Nasios, Grigorios and Dardiotis, Efthimios and Grigoriadis, Nikolaos author-email: 'cbakirtzis@auth.gr artemiadis.artemios@ucy.ac.cy nteli.elli@gmail.com bozikim@auth.gr valeria28289@hotmail.gr cynthia.honan@utas.edu.au lmessinis@upatras.gr nasios@uoi.gr edar@med.uth.gr ngrigoriadis@auth.gr' author_list: - family: Bakirtzis given: Christos - family: Artemiadis given: Artemios - family: Nteli given: Elli - family: Boziki given: Marina Kleopatra - family: Karakasi given: Maria-Valeria - family: Honan given: Cynthia - family: Messinis given: Lambros - family: Nasios given: Grigorios - family: Dardiotis given: Efthimios - family: Grigoriadis given: Nikolaos da: '2023-09-28' doi: 10.3390/healthcare9070897 eissn: 2227-9032 files: [] journal: HEALTHCARE keywords: 'multiple sclerosis; employment; patient-reported outcome; MSWDQ-23; validation' keywords-plus: 'INTERNATIONAL COGNITIVE ASSESSMENT; IMPACT SCALE; EMPLOYMENT; DISABILITY; PEOPLE; VALIDITY; RELIABILITY; IMPAIRMENT; FATIGUE; RESERVE' language: English month: JUL number: '7' number-of-cited-references: '44' orcid-numbers: 'Boziki, Marina/0000-0002-6601-5163 Karakasi, Valeria/0000-0002-5026-0842 Bakirtzis, Christos/0000-0002-4737-3707 GRIGORIADIS, NIKOLAOS/0000-0002-4278-3301 Dardiotis, Efthimios/0000-0003-2957-641X Artemiadis, Artemios/0000-0001-9435-9644 Honan, Cynthia/0000-0001-5735-4270 NASIOS, GRIGORIOS/0000-0001-7495-6863' papis_id: 69cc2edb88d25ca14da853e7fb1bdf57 ref: Bakirtzis2021greekvalidation researcherid-numbers: 'Boziki, Marina/ACF-8768-2022 Karakasi, Valeria/IRZ-8890-2023 Bakirtzis, Christos/AAV-9163-2020 Messinis, Lambros/HIK-2587-2022 Honan, Cynthia/O-6332-2017 ' times-cited: '3' title: A Greek Validation Study of the Multiple Sclerosis Work Difficulties Questionnaire-23 type: article unique-id: WOS:000676759000001 usage-count-last-180-days: '0' usage-count-since-2013: '0' volume: '9' web-of-science-categories: Health Care Sciences \& Services; Health Policy \& Services year: '2021'