abstract: 'Background: International literature shows unemployment and income loss during the Great Recession worsened population mental health. This individual-level longitudinal study examines how regional economic trends and austerity related to depression using administrative prescription data for a large and representative population sample. Methods: Records from a sample of the Scottish Longitudinal Study (N=86 500) were linked to monthly primary care antidepressant prescriptions (2009-15). Regional economic trends were characterized by annual full-time employment data (2004-14). Economic impact of austerity was measured via annual income lost per working age adult due to welfare reforms (2010-15). Sequence analysis identified new cases of antidepressant use, and group-based trajectory modelling classified regions into similar economic trajectories. Multi-level logistic regression examined relationships between regional economic trends and new antidepressant prescriptions. Structural equation mediation analysis assessed the contributory role of welfare reforms. Results: Employed individuals living in regions not recovering post-recession had the highest risk of beginning a new course of antidepressants (AOR 1.23; 95\% CI 1.08-1.38). Individuals living in areas with better recovery trajectories had the lowest risk. Mediation analyses showed that 50\% (95\% CI 7-61 \%) of this association was explained by the impact of welfare benefit reforms on average incomes. Conclusions: Following the Great Recession, local labour market decline and austerity measures were associated with growing antidepressant usage, increasing regional inequalities in mental health. The study evidences the impact of austerity on health inequalities and suggests that economic conditions and welfare policies impact on population health. Reducing the burden of mental ill-health primarily requires action on the social determinants.' affiliation: 'Pearce, J (Corresponding Author), Univ Edinburgh, Sch GeoSci, Ctr Res Environm Soc \& Hlth, Edinburgh EH8 9XP, Midlothian, Scotland. Cherrie, Mark; Curtis, Sarah; Baranyi, Gergo; Dibben, Chris; Pearce, Jamie, Univ Edinburgh, Sch GeoSci, Ctr Res Environm Soc \& Hlth, Edinburgh EH8 9XP, Midlothian, Scotland. Curtis, Sarah, Univ Durham, Sch Geog, Durham, England. Cunningham, Niall, Newcastle Univ, Sch Geog Polit \& Sociol, Newcastle Upon Tyne, Tyne \& Wear, England. Dibben, Chris, Univ Edinburgh, ESRC Adm Data Res Ctr, Newcastle Upon Tyne, Tyne \& Wear, England. Bambra, Clare, Newcastle Univ, Fac Med Sci, Populat Hlth Sci Inst, Newcastle Upon Tyne, Tyne \& Wear, England.' author: Cherrie, Mark and Curtis, Sarah and Baranyi, Gergo and Cunningham, Niall and Dibben, Chris and Bambra, Clare and Pearce, Jamie author-email: jamie.pearce@ed.ac.uk author_list: - family: Cherrie given: Mark - family: Curtis given: Sarah - family: Baranyi given: Gergo - family: Cunningham given: Niall - family: Dibben given: Chris - family: Bambra given: Clare - family: Pearce given: Jamie da: '2023-09-28' doi: 10.1093/eurpub/ckaa253 earlyaccessdate: FEB 2021 eissn: 1464-360X files: [] issn: 1101-1262 journal: EUROPEAN JOURNAL OF PUBLIC HEALTH keywords-plus: 'MENTAL-HEALTH; DEPRESSIVE SYMPTOMS; ECONOMIC RECESSION; FINANCIAL CRISIS; WELFARE-REFORM; INEQUALITIES; IMPACT; OUTCOMES; TRENDS; TIMES' language: English month: APR number: '2' number-of-cited-references: '43' orcid-numbers: 'Bambra, Clare l/0000-0002-1294-6851 Baranyi, Gergo/0000-0002-3287-3629 Pearce, Jamie/0000-0002-0994-7140' pages: 297-303 papis_id: cd8dc638610804c7ead368ade6f6d1a6 ref: Cherrie2021datalinkage researcherid-numbers: 'Bambra, Clare l/C-1392-2010 ' times-cited: '4' title: A data linkage study of the effects of the Great Recession and austerity on antidepressant prescription usage type: article unique-id: WOS:000667794000013 usage-count-last-180-days: '1' usage-count-since-2013: '11' volume: '31' web-of-science-categories: Public, Environmental \& Occupational Health year: '2021'