abstract: 'Background Impacts of early childhood development (ECD) interventions

  (such as fostering attachment and responsiveness through communication,

  play and stimulation) are well known. Globally, there is increasing

  recognition of the importance of the `golden'' minutes, hours and days

  after birth for infant health and development. However, only one

  systematic review has examined ECD interventions implemented in the

  neonatal period (0-27 days), and this review only assessed interventions

  implemented by specialised providers. Primary care providers have many

  potential contacts with mothers and infants throughout the neonatal

  period. However, it is unclear how many research studies or programmes

  have examined the effectiveness of ECD interventions commencing in the

  neonatal period and which methods were used. To date, there has been no

  systematic review of the effect of ECD interventions delivered by

  primary care providers commencing in the neonatal period. Methods Our

  overall aim is to conduct a systematic review of the effect of ECD

  interventions implemented by primary care providers in the neonatal

  period. We will assess effects by timing and number (''dose'') of contacts

  with primary care providers. Subgroup assessment will include effects in

  disadvantaged infants such as those born with low birth weight and to

  mothers with mental health disorders. We will also assess effects in

  low- and high-income countries and by type of care provider. The primary

  outcome is cognitive status in children aged 0-23 months as measured

  using standardised scales. Secondary outcomes include other child

  neurodevelopment domains (speech, language, fine motor, gross motor,

  social, emotional, behaviour, executive functioning, adaptive

  functioning) in children aged 0-23 months. Effects on maternal mental

  health will also be assessed between 0-23 months postpartum. Databases

  such as MEDLINE (OVID), PsycINFO (OVID), EMBASE (OVID), CINAHL, Cochrane

  Library, WHO databases and reference lists of papers will be searched

  for relevant articles. Only randomised controlled trials will be

  included. A narrative synthesis for all outcomes will be reported.

  Meta-analyses will be performed where exposures and outcomes are

  sufficiently homogeneous. Guidelines for PRISMA-P (Preferred Reporting

  Items for Systematic Reviews and Meta-Analyses Protocols) will be

  followed. Discussion This review appears to be the first to be conducted

  in this area. The findings will be an important resource for

  policymakers, primary care providers and researchers who work with young

  infants in primary care settings. Systematic review registration

  PROSPERO'
affiliation: 'Edmond, KM (Corresponding Author), Univ Western Australia, Med Sch,
  Div Paediat, Perth, WA, Australia.

  Edmond, Karen M.; Strobel, Natalie A.; Adams, Claire; McAullay, Dan, Univ Western
  Australia, Med Sch, Div Paediat, Perth, WA, Australia.'
article-number: '224'
author: Edmond, Karen M. and Strobel, Natalie A. and Adams, Claire and McAullay, Dan
author-email: karen.edmond@uwa.edu.au
author_list:
- family: Edmond
  given: Karen M.
- family: Strobel
  given: Natalie A.
- family: Adams
  given: Claire
- family: McAullay
  given: Dan
da: '2023-09-28'
doi: 10.1186/s13643-019-1142-1
eissn: 2046-4053
files: []
journal: SYSTEMATIC REVIEWS
keywords: Primary care; Early childhood development; Neonatal; Cognition
keywords-plus: 'NUTRITION INTERVENTIONS; RESPONSIVE STIMULATION; HEALTH-PROMOTION;

  YOUNG-CHILDREN; PROGRAM; PAKISTAN; GROWTH'
language: English
month: AUG 30
number: '1'
number-of-cited-references: '44'
orcid-numbers: 'Adams, Claire Elizabeth/0000-0002-0667-8088

  Strobel, Natalie A/0000-0002-2962-5704

  McAullay, Daniel/0000-0002-0651-899X'
papis_id: 5f8655d84db153aaba82cd2bc8b1c06f
ref: Edmond2019effectearly
researcherid-numbers: 'Adams, Claire Elizabeth/ABE-8004-2021

  Strobel, Natalie A/O-9174-2014

  '
tags:
- review
times-cited: '3'
title: 'Effect of early childhood development interventions implemented by primary
  care providers commencing in the neonatal period to improve cognitive outcomes in
  children aged 0-23 months: protocol for a systematic review and meta-analysis'
type: Review
unique-id: WOS:000483610400001
usage-count-last-180-days: '1'
usage-count-since-2013: '11'
volume: '8'
web-of-science-categories: Medicine, General \& Internal
year: '2019'