abstract: 'The present study was undertaken to assess the health-related quality of

  life (HRQoL) and burden of illness due to pain and its treatment for

  patients with peripheral neuropathic pain (PNP). It is the first step in

  finding reliable instruments/targets to evaluate treatment outcome in

  this patient population. Study population consisted of 126 patients

  suffering from neuropathic, pain due to a peripheral nerve or root

  lesion, recruited from two multidisciplinary pain clinics. HRQoL was

  examined using Short Form 36 (SF-36) Health Survey and Nottingham Health

  Profile (NHP). Pain intensity in four categories (at rest and evoked by

  movement, touch and cold) was rated on a visual analogue scale (VAS).

  Degree of discomfort from pain and 25 symptoms related to pain and

  side-effects was also assessed. Reduction in workload due to pain was

  recorded, as was the pain relief from previous and current treatments

  and the reasons for discontinuing previous treatments.

  All dimensions in SF-36 and NHP were significantly impaired. SF-36 was a

  valid instrument for describing the impact of pain on the HRQoL of

  patients with PNP. NHP had a lower reliability but has other advantages

  that might be of importance. Many patients experienced poor pain relief

  from ongoing pain treatments. Most previous treatments were discontinued

  owing to lack of efficacy and/or severe side-effects. Many patients

  experienced a high intensity of at least one type of pain; median VAS

  for the highest pain intensity score of each patient (any type of pain)

  was 74/100. Besides pain, patients were most bothered by difficulty in

  sleeping, lack of energy, drowsiness, difficulty in concentrating and

  dry mouth. Employment status was reduced owing to pain in 52\% of the

  patients.

  The intense pain, other troublesome symptoms, limited efficacy and

  tolerability of available treatments, together with the impaired health

  and reduced work status, amount to a substantial burden for patients

  with PNP. (C) 2001 European Federation of Chapters of the International

  Association for the Study of Pain.'
affiliation: 'Astra Pain Control AB, SE-15185 Sodertalje, Sweden.

  Univ Uppsala Hosp, Dept Anesthesiol \& Intens Care, Acad Hosp, SE-75105 Uppsala,
  Sweden.

  Danderyd Hosp, Dept Anesthesiol \& Intens Care, SE-18288 Stockholm, Sweden.'
author: Meyer-Rosberg, K and Kvarnstrom, A and Kinnman, E and Gordh, T and Nordfors,
  LO and Kristofferson, A
author-email: karin.meyer-rosberg@quintiles.com
author_list:
- family: Meyer-Rosberg
  given: K
- family: Kvarnstrom
  given: A
- family: Kinnman
  given: E
- family: Gordh
  given: T
- family: Nordfors
  given: LO
- family: Kristofferson
  given: A
da: '2023-09-28'
doi: 10.1053/eujp.2001.0259
eissn: 1532-2149
files: []
issn: 1090-3801
journal: EUROPEAN JOURNAL OF PAIN
keywords: 'peripheral neuropathic pain; peripheral nerve injury; nerve root lesion;

  SF-36; Nottingham Health Profile; health related quality of life; rating

  scale'
keywords-plus: 'QUALITY-OF-LIFE; RANDOMIZED CONTROLLED TRIAL; HEALTH SURVEY SF-36;

  GABAPENTIN; VALIDITY; DISEASE'
language: English
number: '4'
number-of-cited-references: '25'
orcid-numbers: Gordh, Torsten/0000-0003-1454-3148
pages: 379-389
papis_id: 5a20a2b52ded89796b26acf6eb1de806
ref: Meyerrosberg2001peripheralneuropathi
times-cited: '173'
title: Peripheral neuropathic pain - a multidimensional burden for patients
type: Article
unique-id: WOS:000173508300006
usage-count-last-180-days: '1'
usage-count-since-2013: '17'
volume: '5'
web-of-science-categories: Anesthesiology; Clinical Neurology; Neurosciences
year: '2001'