abstract: 'Background: The social determinants of health have been widely recognised yet there remains a lack of clarity regarding what constitute the macro-economic determinants of health and what can be done to address them. An umbrella review of systematic reviews was conducted to identify the evidence for the health and health inequalities impact of population level macroeconomic factors, strategies, policies and interventions. Methods: Nine databases were searched for systematic reviews meeting the Database of Abstracts of Reviews of Effects (DARE) criteria using a novel conceptual framework. Studies were assessed for quality using a standardised instrument and a narrative overview of the findings is presented. Results: The review found a large (n = 62) but low quality systematic review-level evidence base. The results indicated that action to promote employment and improve working conditions can help improve health and reduce gender-based health inequalities. Evidence suggests that market regulation of tobacco, alcohol and food is likely to be effective at improving health and reducing inequalities in health including strong taxation, or restriction of advertising and availability. Privatisation of utilities and alcohol sectors, income inequality, and economic crises are likely to increase health inequalities. Left of centre governments and welfare state generosity may have a positive health impact, but evidence on specific welfare interventions is mixed. Trade and trade policies were found to have a mixed effect. There were no systematic reviews of the health impact of monetary policy or of large economic institutions such as central banks and regulatory organisations. Conclusions: The results of this study provide a simple yet comprehensive framework to support policy-makers and practitioners in addressing the macroeconomic determinants of health. Further research is needed in low and middle income countries and further reviews are needed to summarise evidence in key gaps identified by this review.' affiliation: 'Naik, Y (Corresponding Author), Leeds Teaching Hosp NHS Trust, Beckett St, Leeds LS9 7TF, W Yorkshire, England. Naik, Y (Corresponding Author), Univ Liverpool, Dept Publ Hlth \& Policy, 3rd Floor,Whelan Bldg,Brownlow Hill, Liverpool L69 3GB, Merseyside, England. Naik, Yannish; Kelly, Gill; Roderick, Peter, Leeds Teaching Hosp NHS Trust, Beckett St, Leeds LS9 7TF, W Yorkshire, England. Naik, Yannish; Barr, Ben, Univ Liverpool, Dept Publ Hlth \& Policy, 3rd Floor,Whelan Bldg,Brownlow Hill, Liverpool L69 3GB, Merseyside, England. Baker, Peter, Imperial Coll London, Global Hlth \& Dev Grp, Sch Publ Hlth, St Marys Campus,Norfolk Pl, London W2 1PG, England. Ismail, Sharif A., London Sch Hyg \& Trop Med, Dept Global Hlth \& Dev, 15-17 Tavistock Pl, London WC1H 9SH, England. Ismail, Sharif A., Imperial Coll London, Dept Primary Care \& Publ Hlth, Reynolds Bldg,St Dunstans Rd, London W6 8RP, England. Tillmann, Taavi, UCL, Inst Global Hlth, Ctr Global Noncommunicable Dis, 30 Guilford St, London WC1N 1EH, England. Bash, Kristin; Black, Michelle, Univ Sheffield, Sch Hlth \& Related Res ScHARR, 30 Regent St, Sheffield S1 4DA, S Yorkshire, England. Quantz, Darryl, Hlth Educ England North West, NW Sch Publ Hlth, First Floor Regatta Pl,Business Pk,Summers Rd, Liverpool L3 4BL, Merseyside, England. Hillier-Brown, Frances, Univ Durham, Dept Sport \& Exercise Sci, 42 Old Elvet, Durham DH1 3HN, England. Jayatunga, Wikum, UCL, Inst Hlth Informat, 222 Euston Rd, London NW1 2DA, England. Bambra, Clare, Newcastle Univ, Fac Med Sci, Royal Victoria Infirm, Sir James Spence Bldg, Newcastle Upon Tyne NE1 4LP, Tyne \& Wear, England.' article-number: '1678' author: Naik, Yannish and Baker, Peter and Ismail, Sharif A. and Tillmann, Taavi and Bash, Kristin and Quantz, Darryl and Hillier-Brown, Frances and Jayatunga, Wikum and Kelly, Gill and Black, Michelle and Gopfert, Anya and Roderick, Peter and Barr, Ben and Bambra, Clare author-email: yannishnaik@nhs.net author_list: - family: Naik given: Yannish - family: Baker given: Peter - family: Ismail given: Sharif A. - family: Tillmann given: Taavi - family: Bash given: Kristin - family: Quantz given: Darryl - family: Hillier-Brown given: Frances - family: Jayatunga given: Wikum - family: Kelly given: Gill - family: Black given: Michelle - family: Gopfert given: Anya - family: Roderick given: Peter - family: Barr given: Ben - family: Bambra given: Clare da: '2023-09-28' doi: 10.1186/s12889-019-7895-6 eissn: 1471-2458 files: [] journal: BMC PUBLIC HEALTH keywords: 'Economy; Social determinants of health; Population health; Economic policy; Health inequalities; Macroeconomy; Public health; Regulation' keywords-plus: 'POPULATION-LEVEL INTERVENTIONS; EXCESSIVE ALCOHOL-CONSUMPTION; INCOME INEQUALITY; ECONOMIC CRISES; WELFARE REGIMES; CHILD HEALTH; MORTALITY; POLICIES; OUTCOMES; POVERTY' language: English month: DEC 17 number: '1' number-of-cited-references: '99' orcid-numbers: 'Ismail, Sharif/0000-0001-7246-7337 Tillmann, Taavi/0000-0002-8428-3719 Bambra, Clare l/0000-0002-1294-6851 Black, Michelle/0000-0002-8358-9150 Barr, Ben R/0000-0002-4208-9475 Jayatunga, Wikum/0000-0002-3063-8975 Hillier-Brown, Frances/0000-0001-9031-4801 Bash, Kristin/0000-0003-3839-3308 Gopfert, Anya/0000-0002-1678-4773' papis_id: ca42c5c613ce8096f76216dba25827ca ref: Naik2019goingupstream researcherid-numbers: 'Ismail, Sharif/ABD-5364-2021 Tillmann, Taavi/R-6026-2016 Bambra, Clare l/C-1392-2010 Black, Michelle/IUL-1582-2023 Barr, Ben R/W-9989-2018 ' tags: - review times-cited: '33' title: Going upstream - an umbrella review of the macroeconomic determinants of health and health inequalities type: Review unique-id: WOS:000511639000001 usage-count-last-180-days: '1' usage-count-since-2013: '24' volume: '19' web-of-science-categories: Public, Environmental \& Occupational Health year: '2019'