abstract: 'IntroductionDespite various efforts to improve human papillomavirus (HPV) vaccine coverage in France, it has always been lower than in most other high-income countries. The health authorities launched in 2018 the national PrevHPV research programme to (1) co-develop with stakeholders and (2) evaluate the impact of a multicomponent complex intervention aimed at improving HPV vaccine coverage amongst French adolescents. ObjectiveTo describe the development process of the PrevHPV intervention using the GUIDance for rEporting of intervention Development framework as a guide. MethodsTo develop the intervention, we used findings from (1) published evidence on effective strategies to improve vaccination uptake and on theoretical frameworks of health behaviour change; (2) primary data on target populations'' knowledge, beliefs, attitudes, preferences, behaviours and practices as well as the facilitators and barriers to HPV vaccination collected as part of the PrevHPV Programme and (3) the advice of working groups involving stakeholders in a participatory approach. We paid attention to developing an intervention that would maximise reach, adoption, implementation and maintenance in real-world contexts. ResultsWe co-developed three components: (1) adolescents'' and parents'' education and motivation using eHealth tools (web conferences, videos, and a serious video game) and participatory learning at school; (2) general practitioners'' e-learning training on HPV using motivational interviewing techniques and provision of a decision aid tool and (3) easier access to vaccination through vaccination days organised on participating middle schools'' premises to propose free of charge initiation of the HPV vaccination. ConclusionWe co-developed a multicomponent intervention that addresses a range of barriers and enablers of HPV vaccination. The next step is to build on the results of its evaluation to refine it before scaling it up if proven efficient. If so, it will add to the small number of multicomponent interventions aimed at improving HPV vaccination worldwide. Patient or Public ContributionThe public (adolescents, their parents, school staff and health professionals) participated in the needs assessment using a mixed methods approach. The public was also involved in the components'' development process to generate ideas about potential activities/tools, critically revise the successive versions of the tools and provide advice about the intervention practicalities, feasibility and maintenance.' affiliation: 'Bocquier, A (Corresponding Author), Universitede Lorraine, UR APEMAC, 9 Ave Foret Haye,BP 20199, F-54505 Nancy, France. Bocquier, Aurelie; Bonnay, Stephanie; Thilly, Nathalie, Univ Lorraine, APEMAC, Nancy, France. Bruel, Sebastien, St Etienne Lyon Univ, Jacques Lisfranc Fac Med, Dept Gen Practice, St etienne, France. Bruel, Sebastien, Univ Claude Bernard, Univ Lyon, Hlth System Proc UR Res Unit 4129, Lyon, France. Michel, Morgane, Univ Paris Cite, ECEVE UMR 1123, Paris, France. Chevreul, Karine, Assistance Publ Hop Paris, URC Eco Ile Defrance Hop Robert Debre, Un epidemiol Clin, Hotel Dieu, Paris, France. Branchereau, Marion, Ctr Reg Coordinat Depistages Canc Pays Loire, Angers, France. Chyderiotis, Sandra, Univ Paris Cite, Inst Pasteur, Emerging Dis Epidemiol Unit, Paris, France. Gauchet, Aurelie, Univ Grenoble Alpes, LIP PC2S, Grenoble, France. Gauchet, Aurelie, Univ Savoie Mont Blanc, LIP PC2S, Chambery, France. Giraudeau, Bruno, Univ Tours, Univ Nantes, SPHERE U1246, INSERM, Tours, France. Giraudeau, Bruno, CHRU Tours, INSERM CIC 1415, Tours, France. Hagiu, Dragos-Paul E., CHU, CIC INSERM 1408, St etienne, France. Mueller, Judith, Univ Rennes, RSMS Rech Serv \& Management Sante U 1309, EHESP, CNRS, Rennes, France. Gagneux-Brunon, Amandine, Univ Lyon, Univ Jean Monnet, Univ Claude Bernard Lyon 1, Ctr Int Rech Infectiol, St etienne, France. Thilly, Nathalie, Univ Lorraine, Dept Methodol Promot Invest, Nancy, France. Bocquier, Aurelie, Universitede Lorraine, UR APEMAC, 9 Ave Foret Haye,BP 20199, F-54505 Nancy, France.' author: Bocquier, Aurelie and Bruel, Sebastien and Michel, Morgane and Le Duc-Banaszuk, Anne-Sophie and Bonnay, Stephanie and Branchereau, Marion and Chevreul, Karine and Chyderiotis, Sandra and Gauchet, Aurelie and Giraudeau, Bruno and Hagiu, Dragos-Paul E. and Mueller, Judith and Gagneux-Brunon, Amandine and Thilly, Nathalie and Group, PrevHPV Study author-email: aurelie.bocquier@univ-lorraine.fr author_list: - family: Bocquier given: Aurelie - family: Bruel given: Sebastien - family: Michel given: Morgane - family: Le Duc-Banaszuk given: Anne-Sophie - family: Bonnay given: Stephanie - family: Branchereau given: Marion - family: Chevreul given: Karine - family: Chyderiotis given: Sandra - family: Gauchet given: Aurelie - family: Giraudeau given: Bruno - family: Hagiu given: Dragos-Paul E. - family: Mueller given: Judith - family: Gagneux-Brunon given: Amandine - family: Thilly given: Nathalie - family: Group given: PrevHPV Study da: '2023-09-28' doi: 10.1111/hex.13778 earlyaccessdate: JUN 2023 eissn: 1369-7625 files: [] issn: 1369-6513 journal: HEALTH EXPECTATIONS keywords: 'co-construction; complex Intervention; eHealth tools; human papillomavirus; motivational interview; vaccination behaviours' keywords-plus: 'HUMAN-PAPILLOMAVIRUS VACCINATION; HEALTH; COMMUNICATION; STRATEGIES; DISEASES; IMPACT' language: English month: OCT number: '5' number-of-cited-references: '64' pages: 1843-1853 papis_id: 0147d2bf5891ee088627c9028d1bc6a7 ref: Bocquier2023codevelopmentschoolb researcherid-numbers: Josselin, LE BEL/GYV-2052-2022 times-cited: '0' title: Co-development of a school-based and primary care-based multicomponent intervention to improve HPV vaccine coverage amongst French adolescents (the PrevHPV Study) type: Article unique-id: WOS:001005704800001 usage-count-last-180-days: '0' usage-count-since-2013: '0' volume: '26' web-of-science-categories: 'Health Care Sciences \& Services; Health Policy \& Services; Public, Environmental \& Occupational Health' year: '2023'