abstract: 'BackgroundAcross diverse regions globally, sex workers continue to face a disproportionate burden of HIV and other sexually transmitted and blood borne infections (STBBIs). Evidence suggests that behavioural and biomedical interventions are only moderately successful in reducing STBBIs at the population level, leading to calls for increased structural and community-led interventions. Given that structural approaches to mitigating STBBI risk beyond HIV among sex workers in high-income settings remain poorly understood, this critical review aimed to provide a comprehensive synthesis of the global research and literature on determinants of HIV and other STBBIs and promising intervention practices for sex workers of all genders in high-income countries.MethodsWe searched for publications over the last decade (January 2005-March 2016) among sex workers (cis women, cis men, and trans individuals). Data obtained from quantitative peer-reviewed studies were triangulated with publicly available reports and qualitative/ethnographic research where quantitative evidence was limited.ResultsResearch demonstrates consistent evidence of the direct and indirect impacts of structural factors (e.g., violence, stigma, criminalization, poor working conditions) on increasing risk for STBBIs among sex workers, further compounded by individual and interpersonal factors (e.g., mental health, substance use, unprotected sex). Sub-optimal access to health and STBBI prevention services remains concerning. Full decriminalization of sex work has been shown to have the largest potential to avert new infections in sex work, through reducing workplace violence and increasing access to safer workspaces. Promising practices and strategies that should be scaled-up and evaluated to prevent STBBIs are highlighted.ConclusionsThe high burden of STBBIs among sex workers across high-income settings is of major concern. This review uniquely contributes to our understanding of multilevel factors that potentiate and mitigate STBBI risk for sex workers of all genders. Research suggests that multipronged structural and community-led approaches are paramount to addressing STBBI burden, and are necessary to realizing health and human rights for sex workers. Given the heterogeneity of sex worker populations, and distinct vulnerabilities faced by cis men and trans sex workers, further research utilizing mixed-methods should be implemented to delineate the intersections of risk and ameliorate critical health inequalities.' affiliation: 'Shannon, K (Corresponding Author), Univ British Columbia, Dept Med, Ctr Gender \& Sexual Hlth Equ, 1190 Hornby St, Vancouver, BC V6Z 2K5, Canada. Shannon, K (Corresponding Author), Univ British Columbia, Sch Populat \& Publ Hlth, Fac Med, 2206 East Mall, Vancouver, BC V6T 1Z9, Canada. Argento, Elena; Goldenberg, Shira; Shannon, Kate, Univ British Columbia, Dept Med, Ctr Gender \& Sexual Hlth Equ, 1190 Hornby St, Vancouver, BC V6Z 2K5, Canada. Argento, Elena, Univ British Columbia, Interdisciplinary Studies Grad Program, 2357 Main Mall, Vancouver, BC V6T 1Z4, Canada. Goldenberg, Shira, Simon Fraser Univ, Fac Hlth Sci, 8888 Univ Dr, Burnaby, BC V5A 1S6, Canada. Shannon, Kate, Univ British Columbia, Sch Populat \& Publ Hlth, Fac Med, 2206 East Mall, Vancouver, BC V6T 1Z9, Canada.' article-number: '212' author: Argento, Elena and Goldenberg, Shira and Shannon, Kate author-email: Dr.Shannon@cgshe.ubc.ca author_list: - family: Argento given: Elena - family: Goldenberg given: Shira - family: Shannon given: Kate da: '2023-09-28' doi: 10.1186/s12879-019-3694-z eissn: 1471-2334 files: [] journal: BMC INFECTIOUS DISEASES keywords: 'Sex workers; HIV prevention; STBBI; Risk environment; High-income countries; Structural interventions' keywords-plus: 'CROSS-SECTIONAL DATA; HIV-PREVENTION; TRANSGENDER WOMEN; CONDOM USE; STRUCTURAL DETERMINANTS; INTERNET ESCORTS; ENGLAND ANALYSIS; SOCIAL COHESION; RISK BEHAVIORS; HEALTH-CARE' language: English month: MAR 5 number-of-cited-references: '112' orcid-numbers: Goldenberg, Shira/0000-0003-1633-9749 papis_id: 34eb224bab70176966d5a615155a94cb ref: Argento2019preventingsexually researcherid-numbers: Goldenberg, Shira/C-9627-2009 tags: - review times-cited: '22' title: 'Preventing sexually transmitted and blood borne infections (STBBIs) among sex workers: a critical review of the evidence on determinants and interventions in high-income countries' type: Review unique-id: WOS:000460516800002 usage-count-last-180-days: '1' usage-count-since-2013: '7' volume: '19' web-of-science-categories: Infectious Diseases year: '2019'