abstract: 'Background: After a first episode of psychosis, cognitive impairments

  present an important barrier to successful (re-)entry into work and

  education. We assessed whether cognitive remediation (CR) as an add-on

  to Individual Placement and Support (IPS) can improve participation in

  regular employment and education.

  Method: Participants with early psychosis (N = 73) were randomly

  assigned to receive IPS supplemented with computerized CR, or IPS plus

  an active control intervention (computer games). The primary outcome was

  the number of hours spent in competitive employment or regular

  education, which was assessed every month during the 18-month study

  period. Secondary outcomes included employment rate, cognitive

  functioning, mental health (assessed at baseline, 6 and 18 months), and

  job duration (assessed after 18 months). Both patients and assessors

  were blind to treatment.

  Results: Participants receiving IPS + CR showed greater improvement of

  competitive employment over time in terms of hours worked (during

  follow-up period: 38.5 vs. 19.6 h, B = 2.94; Wald chi(2) = 5.39; P =

  .02) and employment rate (at T2: 62.1\% vs. 25.9\%, chi 2 = 7.39; df =

  1; P = .008), compared with the IPS + control group, particularly in the

  longer term. The number of hours spent in regular education was lower in

  the IPS + CR group, with more participants having ended education for a

  positive reason. There was a significant beneficial effect of adjunctive

  CR for executive functioning, subjective cognitive functioning, and

  empowerment.

  Conclusions: Augmenting IPS with CR has a significant impact on

  competitive employment in people with early psychosis, with beneficial

  effects being more pronounced after 18 months.'
affiliation: 'van Duin, D (Corresponding Author), Ctr Expertise Severe Mental Illness,
  Da Costakade 45,POB 1203, NL-3500 BE Utrecht, Netherlands.

  van Duin, Danielle; de Winter, Lars; van Weeghel, Jaap, Phrenos Ctr Expertise, Utrecht,
  Netherlands.

  van Duin, Danielle; Kroon, Hans, Trimbos Inst, Tilburg, Netherlands.

  van Duin, Danielle; Kroon, Hans; van Weeghel, Jaap, Tilburg Univ, Tilburg Sch Social
  \& Behav Sci, Tranzo, Tilburg, Netherlands.

  Veling, Wim, Univ Groningen, Groningen, Netherlands.

  Veling, Wim, Univ Med Ctr Groningen, Groningen, Netherlands.'
author: van Duin, Danielle and de Winter, Lars and Kroon, Hans and Veling, Wim and
  van Weeghel, Jaap
author-email: dduin@kephrenos.nl
author_list:
- family: van Duin
  given: Danielle
- family: de Winter
  given: Lars
- family: Kroon
  given: Hans
- family: Veling
  given: Wim
- family: van Weeghel
  given: Jaap
da: '2023-09-28'
doi: 10.1016/j.schres.2021.07.025
earlyaccessdate: SEP 2021
eissn: 1573-2509
files: []
issn: 0920-9964
journal: SCHIZOPHRENIA RESEARCH
keywords: 'Early psychosis; RCT; Individual placement and support; Add-on;

  Cognitive remediation'
keywords-plus: 'IMPLEMENTING SUPPORTED EMPLOYMENT; NEGATIVE SYNDROME SCALE; 1ST EPISODE

  PSYCHOSIS; SEVERE MENTAL-ILLNESS; INDIVIDUAL PLACEMENT;

  VOCATIONAL-REHABILITATION; PSYCHOMETRIC PROPERTIES; 1ST-EPISODE

  PSYCHOSIS; SCHIZOPHRENIA; PEOPLE'
language: English
month: OCT
number-of-cited-references: '59'
orcid-numbers: 'Kroon, Hans/0000-0002-2259-1628

  Veling, Wim/0000-0002-1364-9779'
pages: 115-122
papis_id: 149ec35cb8faaeedc613529b9429cf79
ref: Vanduin2021effectsips
researcherid-numbers: 'Kroon, Hans/I-5683-2016

  '
times-cited: '5'
title: 'Effects of IPS plus cognitive remediation in early psychosis: 18-month functioning
  outcomes of a randomized controlled trial'
type: Article
unique-id: WOS:000701833300018
usage-count-last-180-days: '1'
usage-count-since-2013: '3'
volume: '236'
web-of-science-categories: Psychiatry
year: '2021'