abstract: 'Background Persons experiencing homelessness and vulnerable housing or those with lived experience of homelessness have worse health outcomes than individuals who are stably housed. Structural violence can dramatically affect their acceptance of interventions. We carried out a systematic review to understand the factors that influence the acceptability of social and health interventions among persons with lived experience of homelessness. Methods We searched through eight bibliographic databases and selected grey literature sources for articles that were published between 1994 and 2019. We selected primary studies that reported on the experiences of homeless populations interacting with practitioners and service providers working in permanent supportive housing, case management, interventions for substance use, income assistance, and women- and youth-specific interventions. Each study was independently assessed for its methodological quality. We used a framework analysis to identify key finding and used the GRADE-CERQuaI approach to assess confidence in the key findings. Findings Our search identified 11,017 citations of which 35 primary studies met our inclusion criteria. Our synthesis highlighted that individuals were marginalized, dehumanized and excluded by their lived homelessness experience. As a result, trust and personal safety were highly valued within human interactions. Lived experience of homelessness influenced attitudes toward health and social service professionals and sometimes led to reluctance to accept interventions. Physical and structural violence intersected with low self-esteem, depression and homeless-related stigma. Positive self-identity facilitated links to long-term and integrated services, peer support, and patient-centred engagement. Conclusions Individuals with lived experience of homelessness face considerable marginalization, dehumanization and structural violence. Practitioners and social service providers should consider anti-oppressive approaches and provide, refer to, or advocate for health and structural interventions using the principles of trauma-informed care. Accepting and respecting others as they are, without judgment, may help practitioners navigate barriers to inclusiveness, equitability, and effectiveness for primary care that targets this marginalized population.' affiliation: 'Pottie, K (Corresponding Author), Bruyere Res Inst, CT Lamont Primary Hlth Care Res Ctr, Ottawa, ON, Canada. Pottie, K (Corresponding Author), Univ Ottawa, Dept Family Med, Ottawa, ON, Canada. Magwood, Olivia; Saad, Ammar; Alkhateeb, Qasem; Gebremeskel, Akalewold; Rehman, Asia; Hannigan, Terry; Sun, Annie Huiru; Kendall, Claire; Pottie, Kevin, Bruyere Res Inst, CT Lamont Primary Hlth Care Res Ctr, Ottawa, ON, Canada. Leki, Vanessa Ymele, MyHlth Ctr, PET CT Dept, Mississauga, ON, Canada. Kpade, Victoire, McGill Univ Montreal, Fac Med, Montreal, PQ, Canada. Saad, Ammar; Kendall, Claire; Pottie, Kevin, Univ Ottawa, Sch Epidemiol \& Publ Hlth, Ottawa, ON, Canada. Pinto, Nicole, Univ Guelph, Dept Populat Med, Guelph, ON, Canada. Kendall, Claire; Ponka, David; Pottie, Kevin, Univ Ottawa, Dept Family Med, Ottawa, ON, Canada. Kendall, Claire, OHRI, Ottawa, ON, Canada. Kendall, Claire, St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada. Kozloff, Nicole, Univ Toronto, Ctr Addict \& Mental Hlth, Toronto, ON, Canada. Kozloff, Nicole, Univ Toronto, Dept Psychiat, Toronto, ON, Canada. Kozloff, Nicole, Univ Toronto, Inst Hlth Policy Management \& Evaluat, Toronto, ON, Canada. Tweed, Emily J., Univ Glasgow, MRC CSO Social \& Publ Hlth Sci Unit, Glasgow, Lanark, Scotland.' article-number: e0226306 author: Magwood, Olivia and Leki, Vanessa Ymele and Kpade, Victoire and Saad, Ammar and Alkhateeb, Qasem and Gebremeskel, Akalewold and Rehman, Asia and Hannigan, Terry and Pinto, Nicole and Sun, Annie Huiru and Kendall, Claire and Kozloff, Nicole and Tweed, Emily J. and Ponka, David and Pottie, Kevin author-email: kpottie@uottawa.ca author_list: - family: Magwood given: Olivia - family: Leki given: Vanessa Ymele - family: Kpade given: Victoire - family: Saad given: Ammar - family: Alkhateeb given: Qasem - family: Gebremeskel given: Akalewold - family: Rehman given: Asia - family: Hannigan given: Terry - family: Pinto given: Nicole - family: Sun given: Annie Huiru - family: Kendall given: Claire - family: Kozloff given: Nicole - family: Tweed given: Emily J. - family: Ponka given: David - family: Pottie given: Kevin da: '2023-09-28' doi: 10.1371/journal.pone.0226306 files: [] issn: 1932-6203 journal: PLOS ONE keywords-plus: 'PEOPLES VIEWS; FRAMEWORK; PROGRAM; SERVICE; WOMEN; CARE; PERSPECTIVES; GENDER; DETERMINANTS; PERCEPTIONS' language: English month: DEC 30 number: '12' number-of-cited-references: '105' orcid-numbers: 'Magwood, Olivia/0000-0003-0262-5621 Tweed, Emily J./0000-0001-6659-812X Saad, Ammar/0000-0002-3145-4596 Sun, Annie H./0000-0003-2002-7115 Gebremeskel, Akalewold Tadesse/0000-0001-5141-8018 Pottie, Kevin/0000-0002-1874-8346 Ponka, David/0000-0003-0902-8520 Kozloff, Nicole/0000-0003-1389-1351' papis_id: 934691cef4ef66099d9610f8575fe1cf ref: Magwood2019commontrust researcherid-numbers: 'Pottie, Kevin/ABC-4385-2020 LI, LINGJUAN/IAR-7701-2023 Magwood, Olivia/IST-7319-2023 ' tags: - relevant - review times-cited: '40' title: 'Common trust and personal safety issues: A systematic review on the acceptability of health and social interventions for persons with lived experience of homelessness' type: Review unique-id: WOS:000515092200015 usage-count-last-180-days: '2' usage-count-since-2013: '24' volume: '14' web-of-science-categories: Multidisciplinary Sciences year: '2019'