abstract: 'Background Transgender women ({''''}trans women{''''}), particularly African-American and Latina trans women, have disproportionately high prevalence of HIV in the United States (U.S.). In order to decrease gender dysphoria and overcome discrimination, trans women affirm their gender through social and medical transition, often in contexts of economic hardship and sexual risk. This study qualitatively examined how gender-affirming behaviors enhance or diminish vulnerability to HIV in light of structural and economic barriers to gender transition. Methods We conducted individual interviews with 19 adult trans women in two U.S. cities (Richmond, VA and St. Louis, MO) who reported one or more sexual risk behaviors and recent economic hardship related to employment/income, housing, or food security. Interviews were recorded, transcribed, and analyzed using thematic content analysis. Results The majority (74\%) of trans women were racial/ethnic minorities with mean age of 26.3 years. Gender-affirming behaviors varied with 58\% of trans women having legally changed their name and gender marker; 79\% having initiated hormone therapy; and 11\% having not initiated any medical or legal changes. None had undertaken surgical changes. Findings suggested that the process of gender transitioning resulted in both increasing and decreasing HIV risk. The high need for gender affirmation by male sex partners contributed to trans women''s exposure to sexual objectification, sexual risk behaviors, and conflicting interests in HIV prevention messaging. Loss of housing and employment due to transition along with the high costs of transition products and medical visits increased reliance on sex work and created new obstacles in accessing HIV services. Trans women experienced lower HIV risk as they acquired legal and medical transition services, reshaped interactions with sex partners, and received gender-affirming support by others, including health providers, employers, peers, and housing professionals. Sexual abstinence was viewed as a negative consequence of incomplete transition, although characterized as a period of low HIV risk. Conclusions Structural and policy initiatives that promote safe gender transition and economic stability in trans women may play a critical role in reducing HIV in this population. Addressing the harmful pressures for U.S. trans women to conform to perceived feminine stereotypes may also serve an important role.' affiliation: 'Mayo-Wilson, LJ (Corresponding Author), Indiana Univ, Ctr Sexual Hlth Promot, Dept Appl Hlth Sci, Sch Publ Hlth, 1025 E 7th St, Bloomington, IN 47405 USA. Mayo-Wilson, LJ (Corresponding Author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Social \& Behav Intervent Program, 615 N Wolfe St,Room E5038, Baltimore, MD 21205 USA. Mayo-Wilson, Larissa Jennings; Wagner, Sarah; Timbo, Fatmata, Indiana Univ, Ctr Sexual Hlth Promot, Dept Appl Hlth Sci, Sch Publ Hlth, 1025 E 7th St, Bloomington, IN 47405 USA. Mayo-Wilson, Larissa Jennings, Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Social \& Behav Intervent Program, 615 N Wolfe St,Room E5038, Baltimore, MD 21205 USA. Benotsch, Eric G.; Sawyer, Ashlee N.; Smout, Shelby A., Virginia Commonwealth Univ, Dept Psychol, 806 West Franklin St, Richmond, VA 23284 USA. Grigsby, Sheila; Cathers, Lauretta, Univ Missouri, Coll Nursing, 221 NAB South Campus,Univ Blvd, St Louis, MO 63121 USA. Poteat, Tonia, Univ N Carolina, Dept Social Med, CB 7240, Chapel Hill, NC 27516 USA. Zimmerman, Rick S., Louisiana State Univ Hlth New Orleans, Sch Nursing, 1900 Gravier St,Room 5B14, New Orleans, LA 70112 USA.' article-number: '782' author: Mayo-Wilson, Larissa Jennings and Benotsch, Eric G. and Grigsby, Sheila and Wagner, Sarah and Timbo, Fatmata and Poteat, Tonia and Cathers, Lauretta and Sawyer, Ashlee N. and Smout, Shelby A. and Zimmerman, Rick S. author-email: ljmayowi@iu.edu author_list: - family: Mayo-Wilson given: Larissa Jennings - family: Benotsch given: Eric G. - family: Grigsby given: Sheila - family: Wagner given: Sarah - family: Timbo given: Fatmata - family: Poteat given: Tonia - family: Cathers given: Lauretta - family: Sawyer given: Ashlee N. - family: Smout given: Shelby A. - family: Zimmerman given: Rick S. da: '2023-09-28' doi: 10.1186/s12889-020-08902-3 eissn: 1471-2458 files: [] journal: BMC PUBLIC HEALTH keywords: 'Transgender women; Housing; Employment; Economic; Qualitative; U; s; HIV; Minority' keywords-plus: RISK BEHAVIORS; SEX WORK; MEN; FRAMEWORK; HIV/STI; HEALTH; DRUGS language: English month: MAY 26 number: '1' number-of-cited-references: '41' papis_id: 36fb7e58a393d4015d74b10963106225 ref: Mayowilson2020combinedeffects researcherid-numbers: 'Smout, Shelby/AHD-7847-2022 Sawyer, Ashlee/AAI-3584-2021' times-cited: '18' title: 'Combined effects of gender affirmation and economic hardship on vulnerability to HIV: a qualitative analysis among US adult transgender women' type: article unique-id: WOS:000537860400006 usage-count-last-180-days: '0' usage-count-since-2013: '8' volume: '20' web-of-science-categories: Public, Environmental \& Occupational Health year: '2020'